Category Biology/Biotechnology

Dietary Fiber found to Regulate Gut Bacteria’s use of Tryptophan, Impacting Health

Dietary fibers make our gut bacteria behave healthy
The essential amino acid tryptophan is converted in the large intestine into either beneficial or harmful substances. The research shows that tryptophan contributes to the production of the healthy substances Indole lactic acid (ILA) and Indole propionic acid (IPA) when we consume sufficient amounts of dietary fiber. However, if we do not get enough dietary fiber, tryptophan will be converted into the substance indole, which is associated with adverse health effects. The figure is created with BioRender (biorender.com) by Martin Frederik Laursen. Credit: The figure is created with BioRender (biorender.com) by Martin Frederik Laursen.

We get healthy dietary fiber from consuming fruits, vegetables, and whole grains...

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Beyond CRISPR: seekRNA delivers a New Pathway for Accurate Gene Editing

Beyond CRISPR: seekRNA delivers a new pathway for accurate gene editing
IS1111 and IS110 family features. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-49474-9

Scientists at the University of Sydney have developed a gene-editing tool with greater accuracy and flexibility than the industry standard, CRISPR, which has revolutionized genetic engineering in medicine, agriculture and biotechnology.

SeekRNA uses a programmable ribonucleic acid (RNA) strand that can directly identify sites for insertion in genetic sequences, simplifying the editing process and reducing errors.

The new gene-editing tool is being developed by a team led by Dr. Sandro Ataide in the School of Life and Environmental Sciences. Their findings have been published in Nature Communications.

“We are tremendously excited by the potential for this technology...

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Growth Factors linked to Stem Cell Aging in Bone Marrow Study

How old is your bone marrow?

The immunofluorescence image details the morphology and cell composition of a femur from a middle-aged mouse. Credit: The Jackson Laboratory

Our bone marrow—the fatty, jelly-like substance inside our bones—is an unseen powerhouse quietly producing 500 billion new blood cells every day. That process is driven by hematopoietic stem cells that generate all of the various types of blood cells in our bodies and regenerating themselves to keep the entire assembly line of blood production operating smoothly.

As with any complex system, hematopoietic stem cells lose functionality as they age—and, in the process, contribute to the risk of serious diseases, including blood cancers. We know that the risk of developing aging-associated diseases is different among different individuals...

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Treating the Gut-Brain Connection with B Vitamins to Treat Parkinson’s Disease

A study led by Nagoya University Graduate School of Medicine in Japan has revealed a link between gut microbiota and Parkinson’s disease (PD). The researchers found a reduction in the gut bacteria of genes responsible for synthesizing the essential B vitamins B2 and B7. They also identified a relationship between the lack of these genes and low levels of agents that help maintain the integrity of the intestinal barrier. This barrier prevents toxins from entering the bloodstream, which causes the inflammation seen in PD. Their findings, published in npj Parkinson’s Disease, suggest that treatment with B vitamins to address these deficiencies can be used to treat PD.

PD is characterized by a variety of physical symptoms that hinder daily activities and mobility, such as shaking, slow...

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