Category Biology/Biotechnology

Scientists Solve Mystery of DNA Damage Detection and Repair caused by Sunlight, Alcohol, and Pollution

Mystery of how DNA damage by sunlight, alcohol and pollution is identified so it can be repaired, is solved
Credit: MRC Laboratory of Medical Sciences, MRC Laboratory for Molecular Biology

A collaboration between researchers at the Laboratory of Medical Sciences (LMS) in London and the Laboratory of Molecular Biology (LMB) in Cambridge, has solved a decades-old mystery which could pave the way to better cancer treatments in the future.

The work, which uncovered the basic mechanism of how one of our most vital DNA repair systems recognizes DNA damages and initiates their repair, has eluded researchers for many years. Using cutting edge imaging techniques to visualize how these DNA repair proteins move on a single molecule of DNA, and electron microscopy to capture how they “lock-on” to specific DNA structures, this research opens the way to more effective cancer treatments.

The collabor...

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Scientists devise Method to Secure Earth’s Biodiversity on the Moon

Proposed lunar biorepository could store genetic samples without electricity or liquid nitrogen. New research led by scientists at the Smithsonian proposes a plan to safeguard Earth’s imperiled biodiversity by cryogenically preserving biological material on the moon. The moon’s permanently shadowed craters are cold enough for cryogenic preservation without the need for electricity or liquid nitrogen, according to the researchers.

The paper, published today in BioScience and written in collaboration with researchers from the Smithsonian’s National Zoo and Conservation Biology Institute (NZCBI), Smithsonian’s National Museum of Natural History, Smithsonian’s National Air and Space Museum and others, outlines a roadmap to create a lunar biorepository, including ideas for governance, t...

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Mucus-based bioink could be used to Print and Grow Lung Tissue

translucent gel printed in a grid pattern inside a glass dish on a gloved hand
Researchers developed a mucus-based bioink for 3D-printed lung tissue.
Adapted from ACS Applied Bio Materials 2024, DOI:10.1021/acsabm.4c00579

Lung diseases kill millions of people around the world each year. Treatment options are limited, and animal models for studying these illnesses and experimental medications are inadequate. Now, writing in ACS Applied Bio Materials, researchers describe their success in creating a mucus-based bioink for 3D printing lung tissue. This advancement could one day help study and treat chronic lung conditions.

While some people with lung diseases receive transplants, donor organs remain in short supply...

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Astronomers explain Rapid Formation of Organic Macromolecules in Protoplanetary Disks around Young Stars

Astronomers clarify how organic macromolecules are formed
Schematic depiction of the IOM formation scenario. Credit: Nature Astronomy (2024). https://doi.org/10.1038/s41550-024-02334-4

An international team of researchers led by the University of Bern has used observation-based computer modeling to find an explanation for how macromolecules can form in a short time in disks of gas and dust around young stars. These findings could be crucial for understanding how habitability develops around different types of exoplanets and stars.

Organic macromolecules are regarded as the building blocks of life, as they are of crucial importance for the life-friendly carbon and nitrogen composition of the earth.

Planetary scientists have long assumed that the organic macromolecules that make the Earth suitable for life come from so-called chondrites...

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