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    Category Biology/Biotechnology

    Perception-based Nanosensor Platform could Advance Detection of Ovarian Cancer

    May 17, 2022, Categories  Health/Medical, Biology/Biotechnology

    (1) Eleven single-stranded DNA oligonucleotides wrap SWCNT chiralities to form DNA-SWCNT sensor complexes. (2) The array of sensors is incubated in the sample of interest. (3) The optical response of the sensors is interrogated by high-throughput NIR spectroscopy. (4) The spectroscopic data are fitted to determine the wavelength and intensity of each sensor emission band. (5) The sensor responses are processed into a feature vector (FV) training set. A.U., arbitrary units. (6) ML algorithms are trained and validated for each target protein and their combinations. Seq, sequence; CNT, Carbon nanotubes. (7) Prediction results are evaluated.
    Figure by Zvi Yaari

    Ovarian cancer kills 14,000 women in the United States every year...

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    Study finds Nanomedicine Targeting Lymph Nodes Key to Triple Negative Breast Cancer Treatment

    May 13, 2022, Categories  Health/Medical, Biology/Biotechnology

    Human metastatic breast cancer in the lymph nodes. National Cancer Institute – Visuals Online

    Research from the University of Michigan Rogel Cancer Center could provide a new approach to treating an aggressive form of breast cancer.

    A study led by Duxin Sun, Ph.D., found that targeting the immune microenvironment in lymph nodes and tumors simultaneously led to long-term tumor remission in mice models of metastatic triple negative breast cancer. Further, using nanoparticles to deliver these immune-altering drugs increases treatment efficacy. These results appear in Science Translational Medicine.

    Immunotherapy combined with chemotherapy has been long approved as standard treatment option for triple negative breast cancer but only shows a limited response in patients...

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    Researchers identify Pathway that Regulates Lipid synthesis and contributes to Tumor Survival

    May 12, 2022, Categories  Health/Medical, Biology/Biotechnology

    The alterations are associated with poor outcomes and disease progression. Alterations in metabolic processes are a hallmark of cancer and can lead to a tumor environment that is acidic. As a result, cancer cells must adapt to survive in this inhospitable environment. In a new study published in the journal Cell Reports, Moffitt Cancer Center researchers show that cancer cells in an acidic environment undergo lipid synthesis and accumulation. The team identified the key signaling molecules responsible for these changes and discovered that these alterations are associated with poor outcomes and disease progression among breast cancer patients.

    Cancer cells undergo numerous changes that promote cell survival and continued growth...

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    Diets high in Fiber associated with Less Antibiotic Resistance in Gut Bacteria

    May 12, 2022, Categories  Health/Medical, Biology/Biotechnology

    Healthy adults eating a diverse diet with at least 8-10 grams of soluble fiber a day have fewer antibiotic-resistant microbes in their guts. Soluble fiber is found in foods such as grains, beans, lentils, nuts, and some fruits and vegetables.

    Healthy adults who eat a diverse diet with at least 8-10 grams of soluble fiber a day have fewer antibiotic-resistant microbes in their guts, according to a study published by Agricultural Research Service scientists and their colleagues in mBio.

    Microbes that have resistance to various commonly used antibiotics such as tetracycline and aminoglycoside are a significant source of risk for people worldwide, with the widely held expectation that the problem of antimicrobial resistance (AMR) — the term that refers to bacteria, viruses, and fungi th...

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