Category Biology/Biotechnology

Sugar-Coated Nanoparticles Target Macrophages, Reverse Pulmonary Fibrosis

Stock: sugar, granulated sugar, white sugar (https://pixabay.com/images/id-2510536/)

Nanoparticle platform delivers a nucleotide that blocks production of scar-promoting protein. Scientists at the University of Illinois Chicago have developed a treatment for pulmonary fibrosis by using nanoparticles coated in mannose — a type of sugar — to stop a population of lung cells called macrophages that contribute to lung tissue scarring. The cell-targeting method holds promise for preventing this severe lung scarring disease, which can result in life-threatening complications like shortness of breath.

The researchers say that the treatment is not yet ready to be tested in clinical trials, but its success in relevant animal models is a promising sign that it may be possible to treat the dise...

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Honey holds Potential for Making Brain-like Computer Chips

Photo by Mariana Ibanez on Unsplash

Honey might be a sweet solution for developing environmentally friendly components for neuromorphic computers, systems designed to mimic the neurons and synapses found in the human brain. Hailed by some as the future of computing, neuromorphic systems are much faster and use much less power than traditional computers. WSU Engineers have demonstrated one way to make them more organic too by using honey to make a memristor, a component similar to a transistor that can not only process but also store data in memory.

In a study published in Journal of Physics D, the researchers show that honey can be used to make a memristor, a component similar to a transistor that can not only process but also store data in memory.

“This is a very small device wi...

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Loss of Neurons, Not Lack of Sleep, makes Alzheimer’s Patients Drowsy

Neurons that promote wakefulness in the brain of an Alzheimer’s patient (green). There are far fewer functioning neurons that would be seen in a healthy brain, indicating that the awake system is weakened in this patient. Image by Grinberg Lab

Reviving ‘awake neurons’ could be the solution to their sleepiness. The lethargy that many Alzheimer’s patients experience is caused not by a lack of sleep, but rather by the degeneration of a type of neuron that keeps us awake, according to a study that also confirms the tau protein is behind that neurodegeneration.

The study’s findings contradict the common notion that Alzheimer’s patients sleep during the day to make up for a bad night of sleep and point toward potential therapies to help these patients feel more awake.

The data came fro...

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Burst of Accumulated Zinc shows how the Mineral Boosts Immune Function, suggesting ways to Improve Health

Dudakov Lab postdoctoral fellow Dr. Lorenzo Iovino discovered two ways that zinc helps boost the immune system.Photo by Robert Hood / Fred Hutch News Service

In mice, zinc helps thymus of the immune system regrow and immune-cell recovery after bone marrow transplant. Zinc’s immune-boosting properties are well-established, but scientists haven’t known exactly how it works. In a new study published online March 25 in the journal Blood, Fred Hutchinson Cancer Research Center scientists reveal two ways the mineral supports immunity and suggest how it could be used to improve health.

Using mice, the team discovered that zinc is needed for the development of disease-fighting immune T cells and prompts regeneration of the thymus, the immune organ that produces T cells.

“This study adds ...

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