Category Biology/Biotechnology

Compound provides innovative Pain Relief

Compound 194 (left) was developed by researchers to uncouple the interaction between CRMP2 and the enzyme Ubc9, which indirectly regulates the sodium ion channel NaV1.7. A new study showed that the resulting reduction in sodium currents reduced pain. (Image: Samantha Perez-Miller, Aude Chefdeville and Rajesh Khanna)

Researchers targeted a common sodium ion channel to reverse pain, with positive results that could lead to a non-addictive solution to treat pain. Researchers at the University of Arizona Health Sciences are closer to developing a safe and effective non-opioid pain reliever after a study showed that a new compound they created reduces the sensation of pain by regulating a biological channel linked to pain.

Most people experience pain at some point in their lives, and the...

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Seizure Forecasting with Wrist-Worn Devices possible for People with Epilepsy

medical illustration or graphic of a brain having a seizure representing epilepsy

A new study found patterns could be identified in patients who wear a special wristwatch monitoring device for six to 12 months, allowing about 30 minutes of warning before a seizure occurred. This worked well most of the time for five of six patients studied.

Despite medications, surgery and neurostimulation devices, many people with epilepsy continue to have seizures. The unpredictable nature of seizures is severely limiting. If seizures could be reliably forecast, people with epilepsy could alter their activities, take a fast-acting medication or turn up their neurostimulator to prevent a seizure or minimize its effects.

A new study in Scientific Reports by Mayo Clinic researchers and international collaborators found patterns could be identified in patients who wear a specia...

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Lack of important Molecule in Red Blood Cells causes Vascular Damage in Type 2 Diabetes

röda blodkroppar
Illustration of red blood cells, Pixabay.

Altered function of the red blood cells leads to vascular damage in type 2 diabetes. Results from a new study in cells from patients with type 2 diabetes and mice show that this effect is caused by low levels of an important molecule in the red blood cells. The study by researchers at Karolinska Institutet in Sweden has been published in the journal Diabetes.

It is well known that patients with type 2 diabetes have an increased risk of cardiovascular disease. Overtime type 2 diabetes may damage blood vessels, which could lead to life-threatening complications such as heart attack and stroke...

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Blood Plasma Protein Fibrinogen Interacts Directly with Nerve Cells to Cause Brain Inflammation

Interactions of blood plasma protein fibrinogen with its receptors, cellular prion protein (above) and intercellular adhesion molecule (below), on the surface of neurons are shown with red dots using a method called proximity ligation assay.  The presence of red dots indicates interaction of the target protein with its receptor. Neuronal nuclei are shown in blue.  — Microscopic images courtesy of Lominadze Laboratory, USF Health

Neuroinflammatory diseases, including Alzheimer’s disease and traumatic brain injury, have been linked to deposits of a tough protein known as fibrin, derived from the blood clotting factor fibrinogen. These mesh-like fibrin deposits occur outside blood vessels in the brain, contributing to the death of neurons that eventually leads to impaired memory.

Now...

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