Category Biology/Biotechnology

Researchers discover ‘Trojan Horse’ Virus Hiding in Human Parasite

Apocryptovirus odysseus (Ao) genome. From (rnaspades 3.15.5) assembly of the Ngô RNA sequencing dataset (SRR1205923), we recovered a high-coverage (123× coverage) RdRp-encoding contig, and identified a second correlated contig of likely viral origin. Contig 2 (279× coverage) contains two putative ORFs: pORF1 and pORF2, but these ORFs do not have identifiable homologs via BLASTp in the non-redundant and transcriptome shotgun assembly databases (date accessed: June 2023), TBLASTN with the nucleotide database, or by InterProScan or HHpred (date accessed: June 2023). Inlay, unbranched assembly graphs (Bandage 0.8.1) of both contigs confirmed a linear genome structure.
Apocryptovirus odysseus (Ao) genome. From (RNASPADES 3.15.5) assembly of the Ngô RNA sequencing dataset (SRR1205923), we recovered a high-coverage (123× coverage) RdRp-encoding contig, and identified a second correlated contig of likely viral origin. Contig 2 (279× coverage) contains two putative ORFs: pORF1 and pORF2, but these ORFs do not have identifiable homologs via BLASTp in the non-redundant and transcriptome shotgun assembly databases (date accessed: June 2023), TBLASTN with the nucleotide database, or by InterProScan or HHpred (date accessed: June 2023). Inlay, unbranched assembly graphs (Bandage 0.8.1) of both contigs confirmed a linear genome structure.

An international team led by researchers at the University of Toronto has found a new RNA virus that they believe is h...

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Immunotherapy Significantly Increases the Number of Patients Free from Bowel Cancer: Clinical trial

chemotherapy
Credit: Unsplash/CC0 Public Domain

An immunotherapy drug given before surgery instead of chemotherapy meant that over ten times more patients with a certain genetic profile were cancer-free after surgery, according to clinical trial results presented by researchers at UCL and UCLH.

The findings, presented at the American Society of Clinical Oncology (ASCO) Annual Meeting 2024, are interim results from the NEOPRISM-CRC phase II clinical trial assessing whether the immunotherapy drug pembrolizumab can improve outcomes for patients with stage two or stage three MMR deficient/MSI-High bowel cancer. The trial was a collaboration among UCL, UCLH, the Christie NHS Foundation Trust in Manchester, St...

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‘Sticky and Strain-Gradient Artificial Epineurium’ can Heal Severed Nerves in only One Minute, Study Claims

Revolutionary 'sticky and strain-gradient artificial epineurium' heals severed nerves in only one minute instead of traditional suturing
Human skin-inspired design of sticky and strain-gradient artificial epineurium (SSGAE) and its tissue-adhesion characteristics. Credit: Korea University College of Medicine

A novel medical advancement termed the “sticky and strain-gradient artificial epineurium” (SSGAE) has been developed, demonstrating remarkable efficacy in rapidly healing severed nerves without traditional microsurgical suturing techniques.

This innovation, spearheaded by a collaborative effort between Professor Jong Woong Park from Orthopedic Surgery, Korea University College of Medicine, Professor Donghee Son from Sungkyunkwan University Department of Superintelligence Engineering, and Professor Mikyung Shin from the Department of Biomedical Engineering, presents a significant breakthrough in nerve repair surge...

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Eating More Fruits and Vegetables may Lead to Optimal Sleep Duration

fruits and vegetables
Credit: Pixabay/CC0 Public Domain

Good health depends on a healthy diet and sufficient exercise and sleep. There are clear associations among these components; for example, good nutrition provides energy for exercise, and many people report that getting enough exercise is important to their ability to get enough sleep. So how might nutrition affect sleep?

A new study looks at the connection between fruit and vegetable intake and sleep duration. The research, by a team from Finland’s University of Helsinki, National Institute for Health and Welfare, and Turku University of Applied Sciences, is published in Frontiers in Nutrition.

Why sleep is important and how it works
Sleep gives our bodies the chance to rest and recover from wakeful activity...

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