Category Biology/Biotechnology

High Cholesterol Fuels Cancer by Fostering Resistance to a form of Cell Death

The proposed model to explain how cancer cells respond to 27HC treatment. Acute (left) treatment with 27HC disrupts lipid metabolism via interfering with SREBPs and LXR signaling, and this results in the inhibition of cell growth and migration. Cancer cells can adapt to the metabolic stress imposed by chronic treatment by 27HC (right). The cells that survive (27HC resistant cells) increase lipid uptake and accommodate the metabolic stress associated with this activity by upregulating the activity of processes that allow them to withstand lipid oxidative stress (ferroptosis); an activity which confers upon them enhanced tumor growth and metastatic capabilities. Numerical source data are reported in the Source Data File.

Chronically high cholesterol levels are known to be associated with...

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Phosphorescent Material inspired by ‘Glow in the Dark’ Wood

Basswood tree
The researchers found that basswood naturally phosphoresces weakly and so mimicked this in their new material. (Credit: Sarka)

Scientists have harnessed the natural ability of wood to faintly glow to develop a new sustainable phosphorescent material that could potentially be used in a wide number of applications, from medical imaging and optical sensing to ‘glow in the dark’ dyes and paints.

An international team of researchers led by North East Forestry University (China) and the University of Bath (UK) investigated the natural phosphorescent properties of lignin, a major component of wood.

Room-temperature phosphorescence (RTP) is when a material absorbs energy with a short wavelength (such as UV light) and then emits it as visible light...

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Eyes provide peek at Alzheimer’s Disease Risk

Amyloid deposits tagged by curcumin fluoresce in a retinal scan. Photo credit: NeuroVision

Amyloid plaques are protein deposits that collect between brain cells, hindering function and eventually leading to neuronal death. They are considered a hallmark of Alzheimer’s disease (AD), and the focus of multiple investigations designed to reduce or prevent their formation, including the nationwide A4 study.

But amyloid deposits may also occur in the retina of the eye, often in patients clinically diagnosed with AD, suggesting similar pathologies in both organs...

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Smallest Biosupercapacitor provides Energy for Biomedical Applications

A research team from Chemnitz University of Technology, IFW Dresden and IPF Dresden present a biocompatible energy storage device in the current issue of Nature Communications. In the picture: An array of 90 tubular nano-biosupercapacitors (nBSCs) on the fingertip enable autarkic operation of sensors in blood. Photo: Research Group Prof. Dr. Oliver G. Schmidt

The miniaturization of microelectronic sensor technology, microelectronic robots or intravascular implants is progressing rapidly. However, it also poses major challenges for research. One of the biggest is the development of tiny but efficient energy storage devices that enable the operation of autonomously working microsystems — in more and more smaller areas of the human body for example...

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