Category Biology/Biotechnology

A high-fat diet disrupts the biology of the gut’s inner lining and its microbial communities — and promotes the production of a metabolite that may contribute to heart disease, according to a study published Aug. 13 in the journal Science.

The discoveries in animal models support a key role for the intestines and microbiota in the development of cardiovascular disease, said Mariana Byndloss, DVM, PhD, assistant professor of Pathology, Microbiology and Immunology at Vanderbilt University Medical Center.

The intestines, she noted, have been relatively understudied by scientists seeking to unders...

The autoimmune disease lupus may be triggered by a defective process in the development of red blood cells (RBCs), according to a study led by researchers at Weill Cornell Medicine. The discovery could lead to new methods for classifying and treating patients with this disease.

The researchers, who published their findings August 11 in Cell, found that in a number of lupus patients, maturing red blood cells fail to get rid of their mitochondria — tiny molecular reactors that help convert oxygen into chemical energy in most cell types, but are normally excluded from red blood cells...

The discovery that the anaesthetic ketamine can help people with severe depression has raised hopes of finding new treatment options for the disease. Researchers at Karolinska Institutet in Sweden have now identified novel mechanistic insights how the drug exerts its antidepressant effect. The findings have been published in the journal Molecular Psychiatry.

According to the World Health Organization, depression is a leading cause of disability worldwide and the disease affects more than 360 million people every year.

The risk of suffering is affected by both genetics and environmental factors. The most commonly prescribed antidepressants, such as SSRIs, affect nerve signalling via monoamines in the brain...

New sensor provides quick test to measure antibiotic resistance. UBC researchers have developed a method for monitoring bacterial responses to antibiotics in health-care settings that opens the door to personalized antibiotic therapy for patients.

Using microwave sensing technology, UBC Okanagan Assistant Professor Mohammad Zarifi and his team at the Okanagan Microelectronics and Gigahertz Applications (OMEGA) Lab have developed a low-cost, contactless, portable and reusable microwave sensor that acts as a fast and reliable evaluation tool for measuring antibiotic resi...