Category Biology/Biotechnology

Cholesterol-craving cancers need lipid enzymes to use metabolites for growth, study shows

tumor cells
Credit: Unsplash/CC0 Public Domain

While many American adults are trying to reduce cholesterol levels, certain cancerous tumors have a relentless appetite for the metabolite. Some tumor cells use as much cholesterol as they can access to accelerate their growth beyond the capabilities of normal cells.

Turning tumors’ cholesterol cravings into weakness
Scientists at Sanford Burnham Prebys Medical Discovery Institute and their collaborators at the University of Illinois Chicago have published findings in Science Advances regarding a potential method for turning the tables on these tumors by subverting their cholesterol cravings. The researchers revealed new insights into enzymes that help move cholesterol around cells...

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Why energy fades with age: Missing membrane lipid may destabilize mitochondria

The Hidden Chemistry of Aging Mitochondria
As we age, mitochondria lose flexibility and energy efficiency. The membrane lipid phosphatidylcholine plays a key role in this process: when its production decreases, mitochondrial function deteriorates significantly. Credit: FLI / Kerstin Wagner; AI-generated with Google Gemini

Why do cells age—and why do we lose our energy and vitality as we get older? This question is one of the central challenges of modern biomedicine. The focus is particularly on mitochondria—tiny cellular organelles long known as the cell’s powerhouses but now understood as dynamic control centers that not only produce energy, but also coordinate cellular communication, adaptation, and many of the processes essential for life.

They supply us with the energy that our body needs for movement, growth, and re...

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Common food preservatives linked to high blood pressure and heart disease

Common food preservatives linked to high blood pressure and heart disease
Common food preservatives linked to high blood pressure and heart disease. Credit: Mathilde Touvier

Eating foods that contain common preservative food additives may increase the risks of high blood pressure and cardiovascular disease, according to research published in the European Heart Journal.

The research was led by Dr. Mathilde Touvier, a research director at INSERM (the French National Institute for Health and Medical Research), and Anaïs Hasenböhler, Ph.D. student, both from the Nutritional Epidemiology Research Team at the Université Sorbonne Paris Nord and Université Paris Cité, France.

Ms. Hasenböhler said, “Food preservatives are used in hundreds of thousands of industrially processed foods...

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For real heart protection, the weekly exercise number climbs far beyond current advice

running
Credit: Unsplash/CC0 Public Domain

Adults should aim to do between 560 and 610 minutes a week of moderate to vigorous physical activity to achieve a substantial reduction in the risk of heart attacks and stroke, suggest the findings of an observational study published in the British Journal of Sports Medicine.

This is between three to four times higher than the current public health recommendation that adults do at least 150 minutes a week of moderate to vigorous physical exercise such as brisk walking, running, or cycling.

People who are less fit need to do slightly more exercise than those who are very fit to get the same cardiovascular benefits, the study suggests.

The researchers say that the current one-size-fits-all advice on exercise may need to be changed and replaced ...

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