Category Biology/Biotechnology

An Illuminating Possibility for Stroke Treatment: Nano-Photosynthesis

Brain slices of mice that received nano-photosynthetic therapy (right) have fewer damaged neurons, shown in green, than control mice (left).
Credit: Adapted from Nano Letters 2021, DOI: 10.10.21/acs.nanolett.1c00719

Blocked blood vessels in the brains of stroke patients prevent oxygen-rich blood from getting to cells, causing severe damage. Plants and some microbes produce oxygen through photosynthesis. What if there was a way to make photosynthesis happen in the brains of patients? Now, researchers reporting in ACS’ Nano Letters have done just that in cells and in mice, using blue-green algae and special nanoparticles, in a proof-of-concept demonstration.

Strokes result in the deaths of 5 million people worldwide every year, according to the World Health Organization...

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Novel Approach Identifies Genes linked to Autism and Predicts Patient IQ

gene
Credit: CC0 Public Domain

According to some estimates, hundreds of genes may be associated with autism spectrum disorders (ASD), but it has been difficult to determine which mutations are truly involved in the disease and which are incidental. New work published in the journal Science Translational Medicine led by researchers at Baylor College of Medicine shows that a novel computational approach can effectively identify genes most likely linked to the condition, as well as predict the severity of intellectual disability in patients with ASD using only rare mutations in genes beyond those already associated with the syndrome.

Knowing which genes contribute to ASD, researchers can then study them to better understand how the condition happens and use them to improve predicting the ri...

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Western Diet may Increase Risk of Gut Inflammation, Infection

A tiny, 3D model of the intestines formed from anti-inflammatory cells known as Paneth cells (green and red) and other intestinal cells (blue) is seen in the image above. Researchers at Washington University School of Medicine in St. Louis and Cleveland Clinic used such models, called organoids, to understand why a Western-style diet rich in fat and sugar damages Paneth cells and disrupts the gut immune system. (Image: Ta-Chiang Liu)

Diet rich in sugar, fat damages immune cells in digestive tracts of mice. Eating a Western diet impairs the immune system in the gut in ways that could increase risk of infection and inflammatory bowel disease, according to a study from researchers at Washington University School of Medicine in St. Louis and Cleveland Clinic.

The study, in mice and peop...

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High-Intensity Intermittent Training improves Spatial Memory in Rats

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Image by Kzenon/Shutterstock

Researchers at the University of Tsukuba found that, despite only covering about one-third of the distance in HIIT compared with that covered in endurance training, similar improvements in exercise capacity and brain function were observed for both forms of exercise.

“We investigated how rats’ muscles and brains — specifically, the region of the brain involved in spatial learning called the hippocampus — adapted to these types of exercise, and how the rats consequently learned and remembered navigating mazes,” explains Professor Hideaki Soya, the principal investigator.

In the experiment, rats were assigned to 1 of 3 groups — resting, endurance running, or alternating intervals (short sprints and rest) — during training sessions on treadmills 5 days/w...

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