Category Biology/Biotechnology

Antibiotics may help to treat Melanoma

Eleonora Leucci: “We need more research and clinical studies to examine the use of antibiotics to treat cancer patients.” The electron microscopy image above represents a human mitochondrion, the ‘power plant’ of the cell. Image created by Roberto Vendramin. 

Some antibiotics appear to be effective against a form of skin cancer known as melanoma. Researchers at KU Leuven, Belgium, examined the effect of these antibiotics on patient-derived tumours in mice. Their findings were published in the Journal of Experimental Medicine.

Researchers from KU Leuven may have found a new weapon in the fight against melanoma: antibiotics that target the ‘power plants’ of cancer cells. These antibiotics exploit a vulnerability that arises in tumour cells when they try to survive cancer therapy.

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Neurotransmitter Levels Predict Math Ability

Neurotransmitter levels predict math ability
Scanning was completed both during Time 1 and Time 2 (approximately 1.5 years later) in each of the 5 age groups (6-year-olds, 10-year-olds, 14-year-olds, 16-year-olds, and 18+-year-olds). Credit: Zacharopoulos G, et al., 2021, PLOS Biology

The neurotransmitters GABA and glutamate have complementary roles—GABA inhibits neurons, while glutamate makes them more active. Published 22nd July in PLOS Biology, researchers led by Roi Cohen Kadosh and George Zacharopoulos from the University of Oxford show that levels of these two neurotransmitters in the intraparietal sulcus of the brain can predict mathematics ability. The study also found that the relationships between the two neurotransmitters and arithmetic fluency switched as children developed into adults.

Levels of brain excitement...

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Study finds unleashing Treg cells may lead to Treatments for Multiple Sclerosis

Genetic deletion of Piezo1 in T cells leads to protection in autoimmunity: In the absence of Piezo1, Tregs expand more and, due to their increased numbers, are more effective in containing the damage inflicted by the effector T cells during an autoimmune neuroinflammation. Effector T cell function is not affected in the absence of Piezo1.
CREDIT
UCI School of Medicine

In a new University of California, Irvine-led study, researchers found that a certain protein prevented regulatory T cells (Tregs) from effectively doing their job in controlling the damaging effects of inflammation in a model of multiple sclerosis (MS), a devastating autoimmune disease of the nervous system.

Published this month in Science Advances, the new study illuminates the important role of Piezo1, a specialized p...

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A New Way to Treat Chronic Wounds

A Spartan-led team is developing an inexpensive biopolymer dressing to heal injuries like diabetic foot ulcers that affect millions of patients all over the world.

Tens of millions of patients around the world suffer from persistent and potentially life-threatening wounds. These chronic wounds, which are also a leading cause of amputation, have treatments, but the cost of existing wound dressings can prevent them from reaching people in need.

Now, a Michigan State University researcher is leading an international team of scientists to develop a low-cost, practical biopolymer dressing that helps heal these wounds.

“The existing efficient technologies are far too expensive for most health care systems, greatly limiting their use in a timely manner,” said Morteza Mahmoudi, an as...

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