Category Biology/Biotechnology

Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a drug candidate that blocks the uptake of glutamine, a key food source for many tumors, and slows the growth of melanoma. The drug is a small molecule that targets a glutamine transporter, SLC1A5, which pumps the nutrient into cancer cells — offering a promising new approach for treating melanoma and other cancers. The study was published in the journal Molecular Cancer Therapeutics.

“While great strides have been made recently in the treatment of melanoma, many patients’ tumors become resistant to therapy, and this has become a major obstacle in the successful treatment of the disease,” says Ze’ev Ronai, Ph.D...

A team of researchers has found disrupting the interaction between cancer cells and certain immune cells is more effective at killing cancer cells than current immunotherapy treatments.

The findings, which include studies in cell lines and animal models, appeared in JCI Insight and focus on a protein called CD6 as a target for a new approach to immunotherapy.

Over the past two decades, new approaches to cancer treatment have been developed that block immune checkpoints, which are receptors on the surface of certain immune cells, like natural killer T cells. Cancer exploits these immune cells and render them dormant.

This treatment, called checkpoint inhibitor immunotherapy, gives these immune cells a chance to fight back...

The massive storm near the gas giant’s equator has been shrinking, but collisions with a series of anticyclones are likely only surface deep. The smaller storms cause chunks of red clouds to flake off, shrinking the larger storm in the process. But the new study found that these disruptions are “superficial.” They are visible to us, but they are only skin deep on the Red Spot, not affecting its full depth.

The ne...

Better detection of the disease may lead to earlier treatment, opportunity to participate in clinical trials. Warning signs for Alzheimer’s disease (AD) can begin in the brain years before the first symptoms appear. Spotting these clues may allow for lifestyle changes that could possibly delay the disease’s destruction of the brain.

“Improving the diagnostic accuracy of Alzheimer’s disease is an important clinical goal. If we are able to increase the diagnostic accuracy of the models in ways that can leverage existing data such as MRI scans, then that can be hugely beneficial,” explained corresponding author Vijaya B. Kolachalama, PhD, assistant professor of medicine at Boston University School of Medicine (BUSM).

Using an advanced AI (artificial intelligence) framework based on...