Category Biology/Biotechnology

Western High-Fat Diet can cause Chronic Pain, according to new study

A typical Western high-fat diet can increase the risk of painful disorders common in people with conditions such as diabetes or obesity, according to a groundbreaking paper authored by a team led by The University of Texas Health Science Center at San Antonio, also referred to as UT Health San Antonio.

Moreover, changes in diet may significantly reduce or even reverse pain from conditions causing either inflammatory pain — such as arthritis, trauma or surgery — or neuropathic pain, such as diabetes. The novel finding could help treat chronic-pain patients by simply altering diet or developing drugs that block release of certain fatty acids in the body.

The paper, more than five years in the making, was published in the June edition of the journal Nature Metabolism by a collabora...

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Secretin Hormone induces Satiation by Activating Brown Fat

fMRI images, showing diminished activity of reward circuits during a food cue task after secretin infusion.

Researchers from the Turku PET Centre and Technical University of Munich have discovered a new mechanism controlling satiation. According to the recently published study, the hormone secretin induces satiation by activating brown adipose tissue.

Brown adipose tissue is known for its ability to generate heat in response to cold exposure. Its activity has been proven to be connected to normal weight and glucose metabolism as well as lesser risks of cardiovascular diseases. Meals have also been shown to increase the thermogenesis in brown fat, but the significance of this phenomenon has been unclear.

  • Secretin is a hormone secreted into blood circulation by the intestines, and ...
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Exposure to Pollutants, Increased Free-radical Damage speeds up Aging

blooming rose, dying rose
A new study by WVU School of Medicine researcher Eric Kelley suggests that unrepaired DNA damage can increase the speed of aging. Kelley and his colleagues genetically modified mice to remove a crucial DNA-repair protein from some of their stem cells. Without this protein, the mice were unable to fix damaged DNA accrued in their immune cells. By the time the genetically modified mice were 5 months old, they resembled a regular two-year-old mouse. For context, a two-year-old mouse is similar in age to an 80-year-old human. (WVU Illustration/Aira Burkhart)

A new study suggests that unrepaired DNA damage can increase the speed of aging. Every day, our bodies face a bombardment of UV rays, ozone, cigarette smoke, industrial chemicals and other hazards.

This exposure can lead to free-rad...

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There’s more to Genes than DNA: How Mum and Dad add something Extra, just for you

Embryos
A normal 4-day-old mouse embryo (L) and an embryo of the same age that has been manipulated to contain maternal chromosomes only (parthenogenote). At this stage, the embryos (blastocysts) appear similar, but the parthenogenote will soon die, underscoring the importance of inheriting imprinted genes from both parents. Different cell types are stained green or red. Credit: Dr Maki Asami.

Biologists at the Universities of Bath and Vienna have discovered 71 new ‘imprinted’ genes in the mouse genome, a finding that takes them a step closer to unravelling some of the mysteries of epigenetics — an area of science that describes how genes are switched on (and off) in different cells, at different stages in development and adulthood.

To understand the importance of imprinted genes to inherit...

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