Category Biology/Biotechnology

A new nanoparticle-based drug can boost the body’s innate immune system and make it more effective at fighting off tumors, researchers at UT Southwestern have shown. Their study, published in Nature Biomedical Engineering, is the first to successfully target the immune molecule STING with nanoparticles about one millionth the size of a soccer ball that can switch on/off immune activity in response to their physiological environment.

“Activating STING by these nanoparticles is like exerting perpetual pressure on the accelerator to ramp up the natural innate immune response to a tumor,” says...

ProAgio, a drug developed by Georgia State University biology professor Zhi-Ren Liu and his team, is effective at treating pancreatic cancer and prolonging survival in mice, according to a study published in the journal Cellular and Molecular Gastroenterology and Hepatology.

A second study, published in the Journal of Experimental Medicine, shows the drug is also effective against triple-negative breast cancer, a fast-growing and hard-to-treat type of breast cancer that carries a poor prognosis.

ProAgio, created from a human protein, targets the cell surface receptor  integrin α_vβ₃ which is expressed on cancer-associated fibroblasts...

Circulation: Heart Failure Journal Report..Dietary information from 3 large, well-known heart disease studies suggests drinking one or more cups of caffeinated coffee may reduce heart failure risk, according to research published today in Circulation: Heart Failure, an American Heart Association journal.

Coronary artery disease, heart failure and stroke are among the top causes of death from heart disease in the U.S. “While smoking, age and high blood pressure are among the most well-known heart disease risk factors, unidentified risk factors for heart disease remain,” according to David P. Kao, M.D...

The material yields soft, elastic objects that feel like human tissue. Researchers in the labs of Christopher Bates, an assistant professor of materials at UC Santa Barbara, and Michael Chabinyc, a professor of materials and chair of the department, have teamed to develop the first 3D-printable “bottlebrush” elastomer. The new material results in printed objects that have unusual softness and elasticity — mechanical properties that closely resemble those of human tissue.

Conventional elastomers, i.e. rubbers, are stiffer than many biological tissues...