Category Biology/Biotechnology

New Drug Form may help treat Osteoporosis, Calcium-related Disorders

Elizabeth Topp, a Purdue professor of physical and industrial pharmacy, helped develop a stabilized form of human calcitonin, which is a peptide drug already used for people with osteoporosis.

A novel form of a drug used to treat osteoporosis that comes with the potential for fewer side effects may provide a new option for patients. The work is supported by the National Institutes of Hqealth and is published in Biophysical Journal.

Purdue University innovators developed a stabilized form of human calcitonin, which is a peptide drug already used for people with osteoporosis. Researchers at Purdue created a prodrug form of the peptide hormone to increase its effectiveness as an osteoporosis treatment.

In humans, calcitonin is the hormone responsible for normal calcium homeostasis...

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Study of 50,000 people finds Brown Fat may Protect against Many Diseases

Brown fat scan
In these PET scans, the person on the left has abundant brown fat around the neck and cervical spine. The person on the right has no detectable brown fat.
(Courtesy of Andreas G. Wibmer and Heiko Schöder)

Brown fat is that magical tissue that you would want more of. Unlike white fat, which stores calories, brown fat burns energy and scientists hope it may hold the key to new obesity treatments. But it has long been unclear whether people with ample brown fat truly enjoy better health. For one thing, it has been hard to even identify such individuals since brown fat is hidden deep inside the body.

Now, a new study in Nature Medicine offers strong evidence: among over 52,000 participants, those who had detectable brown fat were less likely than their peers to suffer cardiac and metabo...

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Novel Film Evaporates Sweat Six Times Faster

One promising application of the novel film is for shoe insoles. It changes colour from blue to pink after absorbing moisture, and can be reused for more than 100 times.

A team of researchers from the National University of Singapore (NUS) has created a novel film that is very effective in evaporating sweat from our skin to keep us cool and comfortable when we exercise, and the moisture harvested from human sweat can be used to power wearable electronic devices such as watches, fitness trackers, and more.

Sweating is a natural process for our body to reduce thermal stress. “Sweat is mostly composed of water. When water is evaporated from the skin surface, it lowers the skin temperature and we feel cooler...

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Gum disease-causing Bacteria borrow Growth Molecules from neighbors to thrive

A cross-species interaction with a symbiotic commensal enables  cell-density-dependent growth and in vivo virulence of an oral pathogen |  The ISME Journal
Model depicting V. parvula (Vp)-P. gingivalis (Pg) interaction during dental biofilm community development.

The human body is filled with friendly bacteria. However, some of these microorganisms, such as Veillonella parvula, may be too nice. These peaceful bacteria engage in a one-sided relationship with pathogen Porphyromonas gingivalis, helping the germ multiply and cause gum disease, according to a new University at Buffalo-led study.

The research sought to understand how P. gingivalis colonizes the mouth. The pathogen is unable to produce its own growth molecules until it achieves a large population in the oral microbiome (the community of microorganisms that live on and inside the body).

The answer: It borrows growth molecules from V...

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