Category Biology/Biotechnology

CRISPR technology to Cure Sickle Cell Disease

Blood smear illustrating sickle cell anemia
This blood smear shows sickle cell disease.

University of Illinois Chicago is one of the U.S. sites participating in clinical trials to cure severe red blood congenital diseases such as sickle cell anemia or Thalassemia by safely modifying the DNA of patients’ blood cells.

The first cases treated with this approach were recently published in an article co-authored by Dr. Damiano Rondelli, the Michael Reese Professor of Hematology at the UIC College of Medicine. The article reports two patients have been cured of beta thalassemia and sickle cell disease after their own genes were edited with CRISPR-Cas9 technology. The two researchers who invented this technology received the Nobel Prize in Chemistry in 2020.

In the paper published in the New England Journal of Medicine, CRISPR-Ca...

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Tiny High-Tech Probes reveal how Information flows across the Brain

Data gathered with Neuropixels, tiny silicon probes capable of recording electrical activity from hundreds of neurons at a time.

A new study from researchers at the Allen Institute collected and analyzed the largest single dataset of neurons’ electrical activity to glean principles of how we perceive the visual world around us. The study, published Wednesday in the journal Nature, captures the hundreds of split-second electrical signals that fire when an animal is interpreting what it sees.

Your brain processes the world around you nearly instantaneously, but there are numerous lightning-fast steps between light hitting your retinas and the point at which you become aware of what’s in front of you...

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NAD+ can restore Age-related Muscle Deterioration, research finds

NAD+ Can Restore Age-Related Muscle Deterioration - EPFL
Scientists at EPFL have discovered that Alzheimer’s-like protein aggregates underly the muscle deterioration seen in aging. But the aggregates can be reversed by boosting the levels of nicotinamide adenine dinucleotide (NAD+), which turns on the defense systems of mitochondria in cells and restores muscle function.

Scientists have discovered that Alzheimer’s-like protein aggregates underly the muscle deterioration seen in aging. But the aggregates can be reversed by boosting the levels of nicotinamide adenine dinucleotide (NAD+), which turns on the defense systems of mitochondria in cells and restores muscle function.

The older we grow, the weaker our muscles get, riddling old age with frailty and physical disability...

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Rapid Blood Test identifies COVID-19 patients at high risk of severe disease

WANDY BEATTYA new study from Washington University School of Medicine in St. Louis suggests that measuring mitochondrial DNA in the blood of patients with COVID-19 can help predict which patients are at highest risk of severe disease, requiring more intensive care. Mitochondrial DNA levels are a measure of tissue damage. Pictured are damaged mitochondria (dark grey areas) released from human lungs. The small dark dots surrounding the mitochondria are magnetic beads that carry antibodies used to isolate and study unhealthy mitochondria that have been released from dying tissues.

Measuring mitochondrial DNA could predict who will need ICU care, intubation...

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