Category Biology/Biotechnology

According to some estimates, chronic pain affects up to 40% of Americans, and treating it frustrates both clinicians and patients — a frustration that’s often compounded by a hesitation to prescribe opioids for pain.

A new study from the University of Michigan School of Dentistry confirms that a low dose of a drug called naltrexone is a good option for patients with orofacial and chronic pain, without the risk of addiction, said first author Elizabeth Hatfield, a clinical lecturer in the Department of Oral and Maxillofacial Surgery and Hospital Dentistry.

Naltrexone is a semisynthetic opioid first developed in 1963 as an oral alternative to naloxone, the nasal spray used to reverse opioid drug overdoses. When prescribed at doses of 50 to 100 milligrams, naltrexone
blocks the effe...

People who eat a Mediterranean-style diet — particularly one rich in green leafy vegetables and low in red meat — are more likely to stay mentally sharp in later life, a study shows.

Closely adhering to a Mediterranean diet was associated with higher scores on a range of memory and thinking tests among adults in their late 70s, the research found.

The study found no link, however, between the Mediterranean-style diet and better brain health. Markers of healthy brain ageing — such as greater grey or white matter volume, or fewer white matter lesions — did not differ between those regularly eating a Mediterranean diet and those who did not.

These latest findings suggest that this primarily plant-based diet may have benefits for cognitive functioning as we get older, researchers...

Algorithm using echocardiogram videos of the heart outperforms other predictors of mortality. Researchers at Geisinger have found that a computer algorithm developed using echocardiogram videos of the heart can predict mortality within a year.

The algorithm – an example of what is known as machine learning, or artificial...

A new nanoparticle-based drug can boost the body’s innate immune system and make it more effective at fighting off tumors, researchers at UT Southwestern have shown. Their study, published in Nature Biomedical Engineering, is the first to successfully target the immune molecule STING with nanoparticles about one millionth the size of a soccer ball that can switch on/off immune activity in response to their physiological environment.

“Activating STING by these nanoparticles is like exerting perpetual pressure on the accelerator to ramp up the natural innate immune response to a tumor,” says...