Category Biology/Biotechnology

Linking Calorie Restriction, Body Temperature and Healthspan

Metabolic adaptation to calorie restrictionScience Signaling, 2020; 13 (648): eabb2490 DOI: 10.1126/scisignal.abb2490

Cutting calories significantly may not be an easy task for most, but it’s tied to a host of health benefits ranging from longer lifespan to a much lower chance of developing cancer, heart disease, diabetes and neurodegenerative conditions such as Alzheimer’s.

A new study from teams led by Scripps Research Professors Bruno Conti, PhD, and Gary Siuzdak, PhD, illuminates the critical role that body temperature plays in realizing these diet-induced health benefits. Through their findings, the scientists pave the way toward creating a medicinal compound that imitates the valuable effects of reduced body temperature.

The research appears in Science Signaling.

Conti has spent...

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A new Twist on DNA Origami

Models and transmission electron microscopy images of various 3D polyhedra that were constructed by connecting the self-linked triangular M-DNA and rectangular M-DNA. From left to right: a tetrahedron, triangular bipyramid, octahedron, pentagonal bipyramid, triangular prism, rectangular prism, pentagonal prism and hexagonal prism

Meta-DNA structures transform the DNA nanotechnology world...

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Children use Both Brain Hemispheres to Understand Language, Unlike Adults

Children use both brain hemispheres to understand language, unlike adults
Examples of individual activation maps in each of the age groups. Strong activation in right-hemisphere homologs of the left-hemispher

Infants and young children have brains with a superpower, of sorts, say Georgetown University Medical Center neuroscientists. Whereas adults process most discrete neural tasks in specific areas in one or the other of their brain’s two hemispheres, youngsters use both the right and left hemispheres to do the same task. The finding suggests a possible reason why children appear to recover from neural injury much easier than adults.

The study published Sept. 7, 2020 in PNAS focuses on one task, language, and finds that to understand language (more specifically, processing spoken sentences), children use both hemispheres...

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Common Class of Drugs linked to increased risk of Alzheimer’s disease

Common anticholinergic drugs like Benadryl linked to increased dementia risk  - Harvard Health Blog - Harvard Health Publishing

A team of scientists, led by researchers at University of California San Diego School of Medicine, report that a class of drugs used for a broad array of conditions, from allergies and colds to hypertension and urinary incontinence, may be associated with an increased risk of cognitive decline, particularly in older adults at greater risk for Alzheimer’s disease (AD).

The findings were published in the September 2, 2020 online issue of Neurology, the medical journal of the American Academy of Neurology.

Anticholinergic drugs are widely used for dozens of conditions, minor and major. Some of these medications require a prescription, while others can be purchased over the counter...

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