Category Biology/Biotechnology

Gene Therapy Research offers hope for people with Chronic Kidney Disease

Gene therapy research offers hope for people with chronic kidney disease
A mechanistic model of AAV9 and AAV-KP1-mediated renal transduction. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-54475-9

Researchers are making strides in improving gene therapies for genetic diseases, particularly chronic kidney disease, using adeno-associated virus, or AAV, vectors. While AAV-based treatments have shown promise, delivering these therapies effectively to the kidneys has remained a challenge—until now.

There are many different types of AAV capsids—the protein shells of virus particles—that have been used to deliver genes to cells, each with unique effects...

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Microplastics found in Multiple Human Organ Tissues Correlated with Lesions

Microplastics found in multiple human organ tissues correlated with lesions
Graphical abstract. Credit: TrAC Trends in Analytical Chemistry (2024). DOI: 10.1016/j.trac.2024.118114

Research led by Zhejiang Agriculture and Forestry University in China has performed a metadata investigation into the presence of microplastics in humans. They report a concerning relationship between micro and nanoplastic (MNP) concentrations in damaged tissues and links with multiple health conditions.

Plastic usage soared from 1.5 million metric tons in the 1950s to nearly 390.7 million in 2021. With the increased use in consumer products came elevated microscopic plastic pollution circulating in soil and waterways, eventually accumulating in the environment, food webs and human tissues.

Consistent methods to pinpoint and quantify MNPs in human tissues are lacking...

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Brain’s ‘Tug-of-War’: Choosing between Classical and Operant Conditioning

brain
Credit: Pixabay/CC0 Public Domain

A study from Tel Aviv University could reshape our scientific understanding of how humans learn and form memories, particularly through classical and operant conditioning.

The research team found that our brain engages in a fierce competition between these two learning systems, and that only one can prevail at any given time. This means that if we try to learn two conflicting actions for the same situation simultaneously, the result will be confusion, making it difficult to perform either action when encountering the situation again.

In their study, the researchers demonstrate this phenomenon in fruit flies...

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Reprogramming Cells for Heart Repair: New Method Transforms Ordinary Fibroblasts into Mature Cardiomyocytes

Researchers from Korea University explore how ascorbic acid and FGF4 revolutionize regenerative medicine
This diagram illustrates how the combination of fibroblast growth factor 4 and ascorbic acid activates the JAK2–STAT3 signaling pathway, promoting the maturation of induced cardiomyocytes (iCMs). This approach effectively reprograms fibroblasts into cardiomyocytes with improved structure and function, offering exciting possibilities for regenerative medicine. Credit: The author

Cardiovascular disease continues to lead as the primary cause of death across the globe, taking millions of lives every year. Damage caused by these diseases is particularly difficult to repair, since the heart has minimal ability to regenerate itself. But what if we could reprogram the body’s own cells to restore damaged tissue?

This question has been tackled by scientists at Korea University, led by Dr...

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