Category Biology/Biotechnology

This new blood test could detect cancer before it shows up on scans

Caption: When the biomarker is detected, the Cas12a protein used for CRISPR cuts the DNA holding the quantum dots, which causes a measurable drop in SHG signal.
Credit: Han Zhang, Shenzhen University

A new CRISPR-powered light sensor can detect the faintest molecular signs of cancer in a drop of blood. A new light-based sensor can spot incredibly tiny amounts of cancer biomarkers in blood, raising the possibility of earlier and simpler cancer detection. The technology merges DNAnanotechnology, CRISPR, and quantumdots to generate a clear signal from just a few molecules. In lung cancer tests, it worked even in real patient serum samples. Researchers hope it could eventually power portable blood tests for cancer and other diseases.

Scientists have designed a powerful light based sensor...

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How bacteria may promote breast cancer

How bacteria may promote breast cancer
SMOX is a key node for breast oncogenesis mediated by multiple pathogenic microbes and pharmacological inhibition of SMOX can serve as an intervention strategy for breast cancer patients harboring microbial dysbiosis. Credits: Drs. Deeptashree Nandi and Dipali Sharma

Researchers at the Johns Hopkins Kimmel Cancer Center have discovered how certain pathogenic bacteria in gut and breast tissue can promote breast cancer development and progression by hijacking a key metabolic enzyme known as spermine oxidase (SMOX). In a study led by Dipali Sharma, Ph.D...

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A common biomarker of schizophrenia and bipolar disorder revealed

A common biomarker of schizophrenia and bipolar disorder
Altered brain connectivity across diagnoses. The meta-analysis revealed consistent alterations in white matter connectivity across psychosis-spectrum disorders, including schizophrenia and bipolar disorder. Credit: Merola et al.

For decades, schizophrenia and bipolar disorder (BD) were treated as distinct and unrelated psychiatric disorders. Schizophrenia is a psychiatric disorder characterized by altered thinking and emotional patterns, hallucinations, false or irrational beliefs (i.e., delusions), cognitive deficits, and disorganized speech. BD, on the other hand, is marked by extreme mood swings, ranging between periods of high-energy (i.e., mania or hypomania) and depressive episodes.

While the symptoms of schizophrenia and BD are markedly different, many patients diagnosed with...

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Microbes harvest metals from meteorites aboard space station

Michael Scott Hopkins performs a microgravity experiment on the International Space Station.
Michael Scott Hopkins performs a microgravity experiment on the International Space Station.

If humankind is to explore deep space, one small passenger should not be left behind: microbes. In fact, it would be impossible to leave them behind, since they live on and in our bodies, surfaces and food. Learning how they react to space conditions is critical, but they could also be invaluable fellows in our endeavor to explore space.

Microorganisms such as bacteria and fungi can harvest crucial minerals from rocks and could provide a sustainable alternative to transporting much-needed resources from Earth.

Researchers from Cornell and the University of Edinburgh collaborated to study how those microbes extract platinum group elements from a meteorite in microgravity, with an experimen...

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