A 2017 photo of Alberto Salleo, associate professor of materials science and engineering, and graduate student Scott Keene characterizing the electrochemical properties of a previous artificial synapse design. Their latest artificial synapse is a biohybrid device that integrates with living cells. (Image credit: L.A. Cicero)
Researchers have created a device that can integrate and interact with neuron-like cells. This could be an early step to an artificial synapse for use in brain-computer interfaces. In 2017, Stanford University researchers presented a new device that mimics the brain’s efficient and low-energy neural learning process...
A newly synthesized version of a fungal compound could be a powerful new tool against cancer vitanovski/Depositphotos
Leading organic chemists synthesize fungal molecule capable of reactivating the self-destruct gene in aggressive cancer cells. Cancers cells use a special technique to propagate; they delete their ‘programmed death’ gene through mutation, ‘forget’ to die when their lifetime is over, and continue to grow instead. A research team has developed a method through which a fungal compound capable of rearming the self-destruct gene in certain cancer cells can be artificially produced in marketable quantities, providing a potential cancer therapeutic strategy.
All human body cells have a certain lifespan, during which they perform their essential duties...
Vitamin D signaling. Production of vitamin D3 and its metabolites 25(OH)D3 and 1,25(OH)2D3 (A). VDR (green) binds accessible genomic DNA in complex with a partner protein (RXR or others, blue) (B). VDR’s DNA binding is supported by the pioneer factors PU.1, CEBPA and/or GABPA. The genomic region that can be influenced by 1,25(OH)2D3 (via binding to VDR) is restricted by CTCF proteins defining left and right TAD borders. Schematic representation of a Voronoi tessellation [55] displaying five TAD classes of the most prominently enriched biological processes (C). The most relevant attributes are the number of persistent and transient VDR sites and were chosen for the x and y axis, respectively.
A good vitamin D status is beneficial both in cancer prevention and in the prognosis of sever...
Persistently engaging in negative thinking patterns may raise the risk of Alzheimer’s disease, finds a new UCL-led study.
In the study of people aged over 55, published in Alzheimer’s & Dementia, researchers found ‘repetitive negative thinking’ (RNT) is linked to subsequent cognitive decline as well as the deposition of harmful brain proteins linked to Alzheimer’s.
The researchers say RNT should now be further investigated as a potential risk factor for dementia, and psychological tools, such as mindfulness or meditation, should be studied to see if these could reduce dementia risk.
Lead author Dr Natalie Marchant (UCL Psychiatry) said: “Depression and anxiety in mid-life and old age are already known to be risk factors for dementia...
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