Category Biology/Biotechnology

Researchers Regrow Damaged Nerves with Polymer and Protein

We’re the first to show a nerve guide without any cells was able to bridge a large, 2-inch gap between the nerve stump and its target muscle,” said senior author Kacey Marra, Ph.D., professor of plastic surgery at Pitt and core faculty at the McGowan Institute for Regenerative Medicine. “Our guide was comparable to, and in some ways better than, a nerve graft.” 

University of Pittsburgh School of Medicine researchers have created a biodegradable nerve guide – a polymer tube – filled with growth-promoting protein that can regenerate long sections of damaged nerves, without the need for transplanting stem cells or a donor nerve.

So far, the technology has been tested in monkeys, and the results of those experiments appeared today in Science Translational Medicine.

“We’...

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Integrating Micro Chips for Electronic Skin

Flexible electronic skin equipped with an array of giant magneto resistance sensors and complex electronics circuit designed and developed for sensing distribution of magnetic field. Photo: Masaya Kondo

Researchers present the first fully integrated flexible electronics made of magnetic sensors and organic circuits which opens the path towards the development of electronic skin. Human skin is a fascinating and multifunctional organ with unique properties originating from its flexible and compliant nature. It allows for interfacing with external physical environment through numerous receptors interconnected with the nervous system. Scientists have been trying to transfer these features to artificial skin for a long time, aiming at robotic applications...

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Solving a Biological Puzzle: How Stress causes Gray Hair

Scientists uncover link between the nervous system and stem cells that regenerate pigment. Scientists have found evidence to support long-standing anecdotes that stress causes hair graying. Researchers found that in mice, the type of nerve involved in the fight-or-flight response causes permanent damage to the pigment-regenerating stem cells in the hair follicle. The findings advance knowledge of how stress impacts the body, and are a first step toward blocking its negative effects.

The study, published in Nature, advances scientists’ knowledge of how stress can impact the body...

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Zebrafish teach Researchers more about Atrial Fibrillation

Stock photo of a zebrafish, which has not been part of the study. Photo: Colourbox
Stock photo of a zebrafish, which has not been part of the study. Photo: Colourbox

Researchers from the Faculty of Health and Medical Sciences have shown a possible link between a genetic variation and the widespread type of cardiac arrhythmia, atrial fibrillation.

The scientists conducted the study in zebrafish, which is a recognised scientific animal model within cardiac research.

Here, researchers from the University of Copenhagen in Denmark and the Max Planck Institute in Germany put special focus on the gene pitx2c. The result came as a surprise to them, says Assistant Professor Pia Lundegaard from the Department of Biomedical Sciences.

‘It seems that we may also have to think of atrial fibrillation as an atrial cardiomyopathy – that is, a challenged heart – rather than...

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