Category Biology/Biotechnology

New molecule could help Improve Heart Attack Recovery

Figure 2.
Molecular modeling of the α carboxyl terminus 1 (αCT
1) and connexin 43 (Cx43) CT
 complex.

Reparative medicine scientists have discovered a new compound that could shield heart tissue before a heart attack, as well as preserve healthy cells when administered after a heart attack. Imagine there were a drug that you could take soon after a heart attack that could reduce damage by protecting healthy heart muscle tissue.

“Cardiologists say that when a heart attack occurs, time is muscle,” said Robert Gourdie, director of the Fralin Biomedical Research Institute at VTC Center for Heart and Reparative Medicine Research.

Without oxygen supplied by blood flow, heart cells die – fast...

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Discovery of Anti-Opioid Pathway offers New Route to designing Safer Pain Medications

Genetic behavioral screen identifies an orphan anti-opioid system. Science, 2019; eaau2078 DOI: 10.1126/science.aau2078

Innovative worm study provides new insights into genetics of addiction-prone drugs. A team at Scripps Research in Florida has discovered a biological system that manages cells’ response to opioid drug exposure. The unexpected discovery offers new ideas for improving the safety of the one of the most effective, and most abused, group of pain medications.

In a paper published as a “First Release,” in the journal Science, lead authors Kirill Martemyanov, PhD, and Brock Grill, PhD, describe how they designed and implemented a new, unbiased approach for decoding the genetic network that controls actions of opioids in a nervous system.

They used a small soil d...

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Tiny Lensless Endoscope captures 3D Images of Objects Smaller than a Cell

Researchers have developed a new self-calibrating endoscope that produces 3D images of objects smaller than a single cell.
Credit: J. Czarske, TU Dresden, Germany

Self-calibrating technology opens new opportunities for medicine and research. Researchers have developed a new self-calibrating endoscope that produces 3D images of objects smaller than a single cell. Without a lens or any optical, electrical or mechanical components, the tip of the endoscope measures just 200 microns across, about the width of a few human hairs twisted together.

As a minimally invasive tool for imaging features inside living tissues, the extremely thin endoscope could enable a variety of research and medical applications...

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Vegetable-rich Diet lowers Fatigue in Multiple Sclerosis patients by raising Good Cholesterol

People prepping vegetables.
Lipid profile is associated with decreased fatigue in individuals with progressive multiple sclerosis following a diet-based intervention: Results from a pilot study. PLOS ONE, 2019; 14 (6): e0218075 DOI: 10.1371/journal.pone.0218075

Fatigue affects majority of MS patients, impacting quality of life and ability to work full time. Higher levels of blood high-density lipoprotein (HDL) may improve fatigue in multiple sclerosis patients, according to a new University at Buffalo-led study.

The pilot study, which investigated the effects of fat levels in blood on fatigue caused by multiple sclerosis, found that lowering total cholesterol also reduced exhaustion.

The results, published recently in PLOS ONE and led by Murali Ramanathan, PhD, professor in the UB School of Pharmacy and Pharma...

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