Category Biology/Biotechnology

Flu virus’ best friend: Low Humidity


Low humidity increases influenza disease through caspase-1/11 activation. WT Mx1 mice or caspase-1/11 KO Mx1 mice were preconditioned at 10% and 50% RH for 5 d and challenged with aerosolized hvPR8 at 2 × 105pfu/mL for 15 min (n = 6 mice per group). (A and B) Weight loss was monitored for 14 d. Data are representative of four experiments and means ± SEM *P < 0.05; one-way ANOVA; Student’s t test.

Yale researchers have pinpointed a key reason why people are more likely to get sick and even die from flu during winter months: low humidity. While experts know that cold temperatures and low humidity promote transmission of the flu virus, less is understood about the effect of decreased humidity on the immune system’s defenses against flu infection.

The Yale research team, led by Ak...

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Common Food Additive Found to Affect Gut Microbiota


Impact of the food additive titanium dioxide (E171) on gut microbiota-host interactionFrontiers in Nutrition, 2019

Titanium dioxide nanoparticles E171 may impact human health. University of Sydney research provides new evidence that nanoparticles, which are present in many food items, may have a substantial and harmful influence on human health. E171 is commonly used in high quantities in foods and some medicines as a whitening agent. Found in more than 900 food products such as chewing gum and mayonnaise, E171 is consumed in high proportion everyday by the general population.

Published in Frontiers in Nutrition, the mice study found that consumption of food containing E171 has an impact on the gut microbiota (defined by the trillions of bacteria that inhabit the gut) which coul...

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New Brain Tumor Imaging technique uses Protein found in Scorpion Venom

A Deathstalker scorpion sits in a jar illuminated by ultraviolet light in a laboratory. Photo by Getty.

A Deathstalker scorpion sits in a jar illuminated by ultraviolet light in a laboratory. Photo by Getty.

A novel imaging technique that uses a synthesized form of scorpion venom to light up brain tumors has shown promise in a clinical trial. The imaging system enables neurosurgeons to better see malignant growths that often are difficult to fully eliminate. Results from the multi-institutional clinical trial, led by investigators from Cedars-Sinai and sponsored by Blaze Bioscience, Inc., appear in the journal Neurosurgery.

The new imaging technique that was studied uses a special high-sensitivity near-infrared camera developed at Cedars-Sinai, along with the imaging agent tozuleristide, or BLZ-100, developed by Blaze...

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Broccoli Sprout compound may Restore Brain Chemistry Imbalance linked to Schizophrenia


Sedlak’s daughter grows broccoli sprouts Credit: Thomas Sedlak

In a series of recently published studies using animals and people, Johns Hopkins Medicine researchers say they have further characterized a set of chemical imbalances in the brains of people with schizophrenia related to the chemical glutamate. And they figured out how to tweak the level using a compound derived from broccoli sprouts.

They say the results advance the hope that supplementing with broccoli sprout extract, which contains high levels of the chemical sulforaphane, may someday provide a way to lower the doses of traditional antipsychotic medicines needed to manage schizophrenia symptoms, thus reducing unwanted side effects of the medicines.

“It’s possible that future studies could show sulforaphane to ...

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