Category Biology/Biotechnology

Scientists reproduce Complete Copy of ‘Anti-Tumor Antibiotic’

Chromoprotein on Kedarcidin, a complex ‘anti-tumour’ antibiotic which scientists have reproduced it synthetically in the lab for the first time.
Credit: Professor Martin Lear, University of Lincoln

Breakthrough reveals new ways to combat drug-resistant bacteria and fight cancer. After 20 years of dedicated research, scientists have cracked the chemical code of an incredibly complex ‘anti-tumour antibiotic’ known to be highly effective against cancer cells as well as drug-resistant bacteria, and have reproduced it synthetically in the lab for the first time.

This major breakthrough and world-first could hail a new era in the design and production of new antibiotics and anticancer agents.

The ‘super substance’ – kedarcidin – was discovered in its natural form by a pharmaceutical c...

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Artificial Mother-of-Pearl created using Bacteria

This abalone shell is a natural form of nacre — also known as mother-of-pearl — an exceptionally tough material found in shells and pearls. Rochester biologists have developed an innovative method for creating nacre in the lab — and maybe on the moon.
Credit: University of Rochester photo / J. Adam Fenster

A biologist invented an inexpensive and environmentally friendly method for making artificial nacre using an innovative component: bacteria. The artificial nacre is made of biologically produced materials and has the toughness of natural nacre, while also being stiff and, surprisingly, bendable. The method used to create the novel material could lead to new applications in medicine, engineering – and even constructing buildings on the moon.

The impressive mechanical properties of...

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How ‘Superbug’ E. coli clones take over human Gut

The researchers investigated how and why a clone of E. coli called ST131 – dubbed a ‘superbug’ because it is resistant to multiple drugs – has become the major cause of drug resistant E. coli infections

A ‘superbug’ clone of E. coli has evolved to prevent itself from becoming so dominant that it could potentially wipe out the bacteria from existence, scientists led by the University of Birmingham have discovered.

The researchers investigated how and why a clone of E. coli called ST131 – dubbed a ‘superbug’ because it is resistant to multiple drugs – has become the major cause of drug resistant E. coli infections, but not so dominant that it has wiped out other clones that do not have multi-drug resistance.

Escherichia coli (E...

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Proofreading the book of life: Gene Editing made Safer

The graphic illustrates the technique described in the new study. A version of the Cas9 protein used in CRISPR gene editing has been mutated. While this protein, seen in blue, retains its proper functioning, it remains “immunosilent”–hidden from predation as a foreign entity by the immune system’s T cells (seen in brown).
Credit: Graphic by Jason Drees

Scientists describe a method of rendering the gene editing tool CRISPR-Cas9 ‘immunosilent,’ potentially allowing the editing and repair of genes to be accomplished reliably and stealthily...

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