Category Biology/Biotechnology

Scientists print 1st 3D Heart using patient’s Biological Materials

A 3D-printed, small-scaled human heart engineered from the patient’s own materials and cells.
Credit: Advanced Science. © 2019 The Authors.

Engineered heart completely matches the immunological, cellular, biochemical and anatomical properties of the patient. In a major medical breakthrough, Tel Aviv University researchers have “printed” the world’s first 3D vascularised engineered heart using a patient’s own cells and biological materials.

Until now, scientists in regenerative medicine – a field positioned at the crossroads of biology and technology – have been successful in printing only simple tissues without blood vessels.

“This is the first time anyone anywhere has successfully engineered and printed an entire heart replete with cells, blood vessels, ventricles and chambers,” says...

Read More

CRISPR-Cas3 innovation holds promise for Disease Cures, advancing science

The new system, called CRISPR-Cas3, can efficiently erase long stretches of DNA from a targeted site in the human genome, a capability not easily attainable in more traditional CRISPR-Cas9 systems. (stock image)
Credit: © MG / Fotolia

A Cornell researcher, who is a leader in developing a new type of gene editing CRISPR system, and colleagues have used the new method for the first time in human cells – a major advance in the field.

The new system, called CRISPR-Cas3, can efficiently erase long stretches of DNA from a targeted site in the human genome, a capability not easily attainable in more traditional CRISPR-Cas9 systems...

Read More

CRISPR-based ‘allelic drive’ allows Genetic Editing with Selective Precision and Broad Implications

Left panel: Gene-drive is mediated by a guide RNA (gRNA) that cuts at the exact site (scissors) where the gene-drive element (blue box: Cas9 gene; yellow box: gRNA) is inserted into the genome, resulting in full gene-drive element copying. Right panel: The new allelic drive is accomplished by the addition of a second gRNA (blue box) to a gene drive element that preferentially cuts a detrimental allele (scissors), but not the beneficial allele, resulting in beneficial allele copying.
Credit: Bier Lab, UC San Diego

Scientists developed a new version of a gene drive that allows the spread of specific, favorable genetic variants, also known as ‘alleles,’ throughout a population...

Read More

Gum Bacteria implicated in Alzheimer’s and other diseases

Bacteria involved in periodontitis have been linked with Alzheimer’s disease, aspiration pneumonia, rheumatoid arthritis and other common disorders. The image is credited to Jan Potempa, University of Louisville.

Scientists trace path of bacterial toxins from the mouth to the brain and other tissues. Researchers are reporting new findings on how bacteria involved in gum disease can travel throughout the body, exuding toxins connected with Alzheimer’s disease, rheumatoid arthritis and aspiration pneumonia. They detected evidence of the bacteria in brain samples from people with Alzheimer’s and used mice to show that the bacterium can find its way from the mouth to the brain.

The bacterium, Porphyromonas gingivalis, is the bad actor involved in periodontitis, the most serious for...

Read More