Category Biology/Biotechnology

‘Molecular Surgery’ Reshapes Living Tissue with Electricity but no Incisions

A new noninvasive process can alter the curve of a cornea from that seen in blue in a) to the new position seen in red in b) to fix vision problems.
Credit: Rachel Qu, Anna Stokolosa, Charlotte Cullip

Traditional surgery to reshape a nose or ear entails cutting and suturing, sometimes followed by long recovery times and scars. But now, researchers have developed a “molecular surgery” process that uses tiny needles, electric current and 3D-printed molds to quickly reshape living tissue with no incisions, scarring or recovery time. The technique even shows promise as a way to fix immobile joints or as a noninvasive alternative to laser eye surgery.

“We envision this new technique as a low-cost office procedure done under local anesthesia,” says Michael Hill, Ph.D...

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Minute Levels of Disease detected with Nanotechnology-enhanced Biochip


a Schematic representation at various stages of biosensor fabrication: (i) Bare electrodes (ii) SAM layer on the bare electrodes (iii) immobilized gold nano particles on the SAM layer (iv) Antibody immobilization on the electrodes (v) antigen–antibody conjugation on the electrodes. b Real image of the biosensor with microchannel

The difficulty in spotting minute amounts of disease circulating in the bloodstream has proven a stumbling block in the detection and treatment of cancers that advance stealthily with few symptoms. With a novel electrochemical biosensing device that identifies the tiniest signals these biomarkers emit, a pair of NJIT inventors are hoping to bridge this gap.

Their work in disease detection is an illustration of the power of electrical sensing – and the gr...

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Next-Generation Single-Dose Antidotes for Opioid Overdoses

Next-generation single-dose antidotes for opioid overdoses
Covalent nanoparticles (top) release naloxone (purple structures) slowly over 24 hours. Credit: Marina Kovaliov

The U.S. opioid epidemic is being driven by an unprecedented surge in deaths from fentanyl and other synthetic opiates. Fentanyl’s powerful effects are long-lasting, and even tiny amounts of the drug can lead to an overdose. Antidotes, such as naloxone, do not last long enough in the body to fully counter the drug, requiring repeated injections. Now, scientists report that they are developing single-dose, longer-lasting opioid antidotes using polymer nanoparticles.

The researchers will present their results today at the American Chemical Society (ACS) Spring 2019 National Meeting & Exposition.

“We became interested in this problem while trying to make non-addictive pa...

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Designer Organelles bring new Functionalities into Cells

The authors see the newly developed synthetic host as a city. On the one hand, typical cellular processes — seen as encapsulated, isolated, and made up of non-interchangeable elements — are represented as repetitive structures: squared, isolated blocks which are always fenced, just like membranous organelles. On the other hand, the image highlights the making of a new organelle — a new building that is not fenced — which is accessible to the rest of the city while having its own identity, a building which is more dynamic and flexible.
Credit: Gemma Estrada Girona

Scientists create membraneless organelle to build proteins in living cell. For the first time, scientists have engineered the complex biological process of translation into a designer organelle in a living mammalian cell...

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