Category Biology/Biotechnology

How does Estrogen Protect Bones? Unraveling a pathway to menopausal bone loss

Estrogen induces osteocyte expression of Sema3A, which acts on its receptor on osteocytes to promote survival, resulting in reduced osteoclastic bone resorption and enhanced osteoblastic bone formation. Sema3A-activated sGC-cGMP signaling through Nrp1 protected osteocytes from apoptosis.
Credit: Department of Cell Signaling,TMDU

Women who have reached menopause are at a greater risk of developing osteoporosis, which can lead to bone fractures and long-term impairment of mobility. Studies have suggested a link between reduced bone density and low estrogen levels due to menopause, but the basis for this link is unclear. Researchers found that the protein Sema3A plays a key role in maintaining healthy bones, suggesting a new therapeutic avenue to treat osteoporosis.

Bone is a complex...

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Potential New Therapy for Liver Diseases

illustration of diseased liver
Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal HypertensionGastroenterology, 2019; DOI: 10.1053/j.gastro.2019.03.013

Drug therapy may effectively treat a potentially life-threatening condition associated with cirrhosis and other chronic liver diseases, according to a new study by Mayo Clinic researchers. The study was posted in March on Gastroenterology, the online journal of the American Gastroenterological Association. Print publication is scheduled for July.

While therapies have been available to treat some forms of liver disease, including hepatitis C and autoimmune hepatitis, options have been more limited for treating portal hypertension, a condition where th...

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High-fructose Corn Syrup boosts Intestinal Tumor Growth in Mice

Soft drink (stock image).
Credit: © Wissam Santina / Fotolia

Does sugar directly feed cancers, boosting their growth? The answer seems to be ‘Yes’ at least in mice according to a study led by researchers at Baylor College of Medicine and Weill Cornell Medicine. Their study, published in Science, showed that consuming a daily modest amount of high-fructose corn syrup – the equivalent of people drinking about 12 ounces of a sugar-sweetened beverage daily – accelerates the growth of intestinal tumors in mouse models of the disease, independently of obesity. The team also discovered the mechanism by which the consumption of sugary drinks can directly feed cancer growth, suggesting potential novel therapeutic strategies.

“An increasing number of observational studies have raised awareness ...

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Dynamic Hydrogel used to make ‘Soft Robot’ Components and LEGO-like building blocks

LEGO-like hydrogel building blocks patterned with tiny fluid channels can be assembled into complex microfluidic devices and then sealed tightly together.
Credit: Wong Lab / Brown University

Using a new type of dual polymer material capable of responding dynamically to its environment, Brown University researchers have developed a set of modular hydrogel components that could be useful in a variety of “soft robotic” and biomedical applications.

The components, which are patterned by a 3D printer, are capable of bending, twisting or sticking together in response to treatment with certain chemicals. For a paper published in the journal Polymer Chemistry, the researchers demonstrated a soft gripper capable of actuating on demand to pick up small objects...

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