Category Biology/Biotechnology

Forgotten cell clusters may hold key to diabetic neuropathy pain

Human dorsal root ganglia in a case of diabetic peripheral neuropathy show formation of Nageotte nodules (circled in pink), which appear to be a strong indicator of nerve cell death.

A phenomenon largely ignored since its discovery 100 years ago appears to be a crucial component of diabetic pain, according to new research from The University of Texas at Dallas’s Center for Advanced Pain Studies (CAPS).

Findings from a new study published in Nature Communications suggest that cell clusters called Nageotte nodules are a strong indicator of nerve cell death in human sensory ganglia. These could prove to be a target for drugs that would protect these nerves or help manage diabetic neuropathy.

“The key finding of our study is really a new view of diabetic neuropathic pain,” said Dr...

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Heart rhythm disorder traced to bacterium lurking in gums

Heart rhythm disorder traced to bacterium lurking in our gums
Immunohistochemical staining in mice shows Porphyromonas gingivalis (green) entering cardiac muscle through small blood vessels in the left atrium. Credit: Shunsuke Miyauchi/Hiroshima University

Tempted to skip the floss? Your heart might thank you if you don’t. A new study from Hiroshima University (HU) finds that the gum disease bacterium Porphyromonas gingivalis (P. gingivalis) can slip into the bloodstream and infiltrate the heart. There, it quietly drives scar tissue buildup—known as fibrosis—distorting the heart’s architecture, interfering with electrical signals, and raising the risk of atrial fibrillation (AFib).

Clinicians have long noticed that people with periodontitis, a common form of gum disease, seem more prone to cardiovascular problems...

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Natural short sleepers have a genetic mutation, finds new study

Natural short sleepers have a genetic mutations finds a new study
A rare genetic mutation was identified in a human with natural short sleep traits. Credit: Ketut Subiyanto/Pexels

Not everyone needs 8 hours of sleep to function properly. Some people can feel well-rested and show no negative effects of sleep deprivation, even after just 4 hours of sleep, which is likely the result of a genetic mutation.

A recent study has reported that a mutation in salt-induced kinase 3 (hSIK3-N783Y)—a gene critical for regulating sleep duration and depth—may be the reason why some people are natural short sleepers (NSS).

The findings of this study are published in Proceedings of the National Academy of Sciences.

We might be physically inactive when sleeping, but our body is far from being idle...

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Black tea and berries could contribute to healthier aging

Hand holding a glass teapot with black tea.
People who consume more flavonoids tend to age better.

Higher intakes of black tea, berries, citrus fruits and apples could help to promote healthy ageing, new research has found.

This study conducted by researchers from Edith Cowan University, Queen’s University Belfast and Harvard T.H. Chan School of Public Health, found that foods rich in flavonoids could help to lower the risk of key components of unhealthy ageing, including frailty, impaired physical function and poor mental health.

“The goal of medical research is not just to help people live longer but to ensure they stay healthy for as long as possible,” ECU Adjunct Lecturer Dr Nicola Bondonno said.

“We know from previous research that people who have a higher flavonoid intake tend to live longer, and they are also les...

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