Category Biology/Biotechnology

Artificial Mother-of-Pearl created using Bacteria

This abalone shell is a natural form of nacre — also known as mother-of-pearl — an exceptionally tough material found in shells and pearls. Rochester biologists have developed an innovative method for creating nacre in the lab — and maybe on the moon.
Credit: University of Rochester photo / J. Adam Fenster

A biologist invented an inexpensive and environmentally friendly method for making artificial nacre using an innovative component: bacteria. The artificial nacre is made of biologically produced materials and has the toughness of natural nacre, while also being stiff and, surprisingly, bendable. The method used to create the novel material could lead to new applications in medicine, engineering – and even constructing buildings on the moon.

The impressive mechanical properties of...

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How ‘Superbug’ E. coli clones take over human Gut

The researchers investigated how and why a clone of E. coli called ST131 – dubbed a ‘superbug’ because it is resistant to multiple drugs – has become the major cause of drug resistant E. coli infections

A ‘superbug’ clone of E. coli has evolved to prevent itself from becoming so dominant that it could potentially wipe out the bacteria from existence, scientists led by the University of Birmingham have discovered.

The researchers investigated how and why a clone of E. coli called ST131 – dubbed a ‘superbug’ because it is resistant to multiple drugs – has become the major cause of drug resistant E. coli infections, but not so dominant that it has wiped out other clones that do not have multi-drug resistance.

Escherichia coli (E...

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Proofreading the book of life: Gene Editing made Safer

The graphic illustrates the technique described in the new study. A version of the Cas9 protein used in CRISPR gene editing has been mutated. While this protein, seen in blue, retains its proper functioning, it remains “immunosilent”–hidden from predation as a foreign entity by the immune system’s T cells (seen in brown).
Credit: Graphic by Jason Drees

Scientists describe a method of rendering the gene editing tool CRISPR-Cas9 ‘immunosilent,’ potentially allowing the editing and repair of genes to be accomplished reliably and stealthily...

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Protecting Damaged Hearts with microRNAs

Fig. 4
\miR-19a/19b promotes cardiomyocyte proliferation after myocardial infarction.

New research advances the possibility of regenerating cardiac tissue after a heart attack. Once the heart is fully formed, the cells that make up heart muscle, known as cardiomyocytes, have very limited ability to reproduce themselves. After a heart attack, cardiomyocytes die off; unable to make new ones, the heart instead forms scar tissue. Over time, this can set people up for heart failure.

New work published April 17th in Nature Communications advances the possibility of reviving the heart’s regenerative capacities using microRNAs – small molecules that regulate gene function and are abundant in developing hearts.

In 2013, Da-Zhi Wang, PhD, a cardiology researcher at Boston Children’s Hospital an...

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