Category Biology/Biotechnology

Technology offers powerful new genetic tools for human disease research in rodents. Using active genetics technology, biologists have developed the world’s first CRISPR/Cas9-based approach to control genetic inheritance in a mammal. The achievement in mice lays the groundwork for further advances based on this technology, including biomedical research on human disease. Future animal models may be possible of complex human genetic diseases, like arthritis and cancer, which are not currently possible.

Scientists around the world have been using CRISPR/Cas9 in a variety of plant and animal species to edit genetic information...

UMD engineers demonstrate their approach by printing the smallest-known 3D microfluidic circuit element. Engineers at the University of Maryland (UMD) have created the first 3D-printed fluid circuit element so tiny that 10 could rest on the width of a human hair. The diode ensures fluids move in only a single direction – a critical feature for products like implantable devices that release therapies directly into the body.

The...

Years before symptoms of Alzheimer’s disease manifest, the brain starts changing and neurons are slowly degraded. Scientists at the German Center for Neurodegenerative Diseases (DZNE), the Hertie Institute for Clinical Brain Research (HIH) and the University Hospital Tuebingen now show that a protein found in the blood can be used to precisely monitor disease progression long before first clinical signs appear. This blood marker offers new possibilities for testing therapies. The study was carried out in cooperation with an international research team and published in the journal Nature Medicine.

“The fact that there is still no effective treatment for Alzheimer’s is partly because current therapies start much too late,” say...

Scientists at Newcastle University have developed a biological system which lets cells form a desired shape by moulding their surrounding material – in the first instance creating a self-curving cornea...