Category Biology/Biotechnology

Researchers create a Wireless, Battery-Free, Biodegradable Blood Flow Sensor

Artist’s depiction of the biodegradable pressure sensor wrapped around a blood vessel with the antenna off to the side (layers separated to show details of the antenna’s structure).
Credit: Levent Beker

Transforming super-sensitive touch sensors, engineers and medical researchers build a way to wirelessly monitor blood flow after surgery. It is biodegradable, battery-free and wireless, so it is compact and doesn’t need to be removed and it can warn a patient’s doctor if there is a blockage.

“Measurement of blood flow is critical in many medical specialties, so a wireless biodegradable sensor could impact multiple fields including vascular, transplant, reconstructive and cardiac surgery,” said Paige Fox, assistant professor of surgery and co-senior author of the paper...

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Brain Plasticity Restored in Adult Mice through Targeting Specific Nerve Cell Connections


Research in mice led by neuroscientists at Tufts University School of Medicine reveals a new molecular mechanism that is essential for brain maturation and may be used to restore plasticity in aged brains. The study focused on a subtype of inhibitory cell also found in people called Parvalbumin neurons (stained in blue) which exert significant power over the timing of the “critical period” for brain maturation. While previous studies had shown that the short-range synapses (green dots) on these neurons affected critical period opening in the brain’s visual cortex (which processes visual scenes), the new study shows that long-range synapses (red dots) on these neurons have a powerful control over critical period closure, despite their lower density in the brain...
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New Materials could ‘Drive Wound Healing’ by harnessing natural healing methods

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Bioinspired aptamers enable the creation of synthetic mimics of the natural TGF‐β1 large latent complex (LLC).

Materials are widely used to help heal wounds: Collagen sponges help treat burns and pressure sores, and scaffold-like implants are used to repair bones. However, the process of tissue repair changes over time, so scientists are developing biomaterials that interact with tissues as healing takes place.

Now, Dr Ben Almquist and his team at Imperial College London have created a new molecule that could change the way traditional materials work with the body. Known as traction force-activated payloads (TrAPs), their method lets materials talk to the body’s natural repair systems to drive healing.

The researchers say incorporating TrAPs into existing medical materials c...

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Engineers create an Inhalable form of Messenger RNA

MIT researchers have designed inhalable particles that can deliver messenger RNA. These lung epithelial cells have taken up particles (yellow) that carry mRNA encoding green fluorescent protein.
Credit: Asha Patel

Patients with lung disease could find relief by breathing in messenger RNA molecules. In an advance that could lead to new treatments for lung disease, researchers have now designed an inhalable form of mRNA. This aerosol could be administered directly to the lungs to help treat diseases such as cystic fibrosis, the researchers say.

mRNA, which can induce cells to produce therapeutic proteins, holds great promise for treating a variety of diseases...

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