Category Biology/Biotechnology

Laughter may be Best Medicine – for Brain Surgery

Illustration showing how an electrode was inserted into the cingulum bundle.
Credit: From Bijanki et al, J. Clin. Invest. (2019); Courtesy of American Society for Clinical Investigation

Effects of electrical stimulation of cingulum bundle. Neuroscientists at Emory University School of Medicine have discovered a focal pathway in the brain that when electrically stimulated causes immediate laughter, followed by a sense of calm and happiness, even during awake brain surgery. The effects of stimulation were observed in an epilepsy patient undergoing diagnostic monitoring for seizure diagnosis. These effects were then harnessed to help her complete a separate awake brain surgery two days later.

The behavioral effects of direct electrical stimulation of the cingulum bundle, a white matte...

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New Disease Surveillance Tool helps Detect any Human-Infecting Virus

A computational method helps scientists examine microbes at a larger, more comprehensive scale than previously possible.
Credit: Susanna M. Hamilton, Broad Communications

A new computational method called ‘CATCH’ designs molecular ‘baits’ for any virus known to infect humans and all their known strains, including those that are present in low abundance in clinical samples, such as Zika. The approach can help small sequencing centers around the globe conduct disease surveillance, which is crucial for controlling outbreaks.

During the Zika virus outbreak of 2015-16, public health officials scrambled to contain the epidemic and curb the pathogen’s devastating effects on pregnant women...

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Simply Shining Light on ‘Dinosaur Metal’ compound Kills Cancer Cells

Iridium with its organic coat which is hooked up to the protein albumin (HSA). Together that enter cancer cells and deliver the iridium photosensitizer to the nucleus. On irradiation with blue light, the iridium not only glows green, but converts oxygen in the cell to a toxic form called triplet oxygen, which kills the cell.
Credit: University of Warwick

A new compound based on Iridium, a rare metal which landed in the Gulf of Mexico 66 M years ago, hooked onto albumin, a protein in blood, can attack the nucleus of cancerous cells when switched on by light, University of Warwick researchers have found...

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Magnetic Teeth hold Promise for Materials and Energy

A single chiton tooth, showing the magnetite cusp.
Credit: Kisailus Biomimetics & Nanostructured Materials Lab

A mollusk with teeth that can grind down rock may hold the key to making next generation abrasion-resistant materials and nanoscale materials for energy. The mollusk, called a gumboot chiton, scrapes algae off ocean rocks using a specialized set of teeth made from the magnetic mineral magnetite. The teeth have the maximum hardness and stiffness of any known biomineral. Although magnetite is a geologic mineral commonly found in Earth’s crust, only a few animals are known to produce it, and little is known about how they make it.

A better understanding of the biomineralization process, combined with a thorough understanding of chiton tooth architecture and mechanics, could h...

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