Category Biology/Biotechnology

Regrowing Damaged Nerves Hinges on Shutting Down Key Genes


Mouse neurons are shown with the cell bodies in the center and long tendrils radiating outward. Valeria Cavalli, PhD, of Washington University School of Medicine in St. Louis, used such neurons to study how cells regrow after injury. Her findings could one day lead to better treatments for spinal cord injury.

Injured neurons temporarily revert to immature state. Neurons in the brain and spinal cord don’t grow back after injury, unlike those in the rest of the body. Cut your finger, and you’ll probably be back to using it in days or weeks; slice through your spinal cord, and you likely will never walk again.

Now, working in mice, researchers at Washington University School of Medicine in St...

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What’s behind Mediterranean Diet and Lower Cardiovascular Risk?

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Assessment of Risk Factors and Biomarkers Associated With Risk of Cardiovascular Disease Among Women Consuming a Mediterranean DietJAMA Network Open, 2018; 1 (8): e185708 DOI: 10.1001/jamanetworkopen.2018.5708

Investigators identify, assess underlying mechanisms that may explain diet’s 25% reduction in cardiovascular risk for American women. A new study by investigators from Brigham and Women’s Hospital, Harvard Medical School, and the Harvard T.H. Chan School of Public Health offers insights from a cohort study of women in the U.S. who reported consuming a Mediterranean-type diet. Researchers found a 25 percent reduction in the risk of cardiovascular disease among study participants who consumed a diet rich in plants and olive oil and low in meats and sweets...

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Inflammatory Bowel Disease linked to Prostate Cancer


Initial PSA value by age and IBD status estimated by longitudinal mixed-effect regression.

Men with inflammatory bowel disease have 4 to 5 times higher risk of being diagnosed with prostate cancer, reports a 20-year study from Northwestern Medicine. This is the first report to show men with inflammatory bowel disease have higher than average PSA (prostate-specific antigen) values, and this group also has a significantly higher risk of potentially dangerous prostate cancer.

About 1 million men have inflammatory bowel disease in the U.S. Inflammatory bowel disease is a common chronic condition that includes Crohn’s disease and ulcerative colitis. “These patients may need to be screened more carefully than a man without inflammatory bowel disease,” said lead study author Dr...

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Sensors developed to Detect and Measure Cancer’s ability to spread

A tumor cell that has acquired high metastatic potential during chemotherapy lights up with high FRET biosensor readout, whereas the cells that are sensitive to chemotherapy (and hence, low potential) stays dark.

Researchers engineered sensors to detect and measure the metastatic potential of single cancer cells. Metastasis is attributed as the leading cause of death in people with cancer.
Cancer would not be so devastating if it did not metastasize,” said Pradipta Ghosh, MD, professor in the UC San Diego School of Medicine departments of Medicine and Cellular and Molecular Medicine, director of the Center for Network Medicine and senior study author.

“Although there are many ways to detect metastasis once it has occurred, there has been nothing available to ‘see’ or ‘measure’ the potentia...

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