Category Biology/Biotechnology

Myocardial Infarction Produces Sustained Proinflammatory Endothelial Activation in Remote Arteries

Cells and platelets stick inside arteries, increase risk after initial attack. Doctors have long known that in the months after a heart attack or stroke, patients are more likely to have another attack or stroke. Now, a paper in the Journal of the American College of Cardiology explains what happens inside blood vessels to increase risk – and suggests a new way to treat it.

Heart attacks in mice caused inflammatory cells and platelets to more easily stick to the inner lining of arteries throughout the body – and particularly where there was already plaque, according to the paper...

Researchers have designed a synthetic small protein that wraps around a metal core composed of iron and sulfur. This protein can be repeatedly charged and discharged, allowing it to shuttle electrons within a cell. Such peptides may have existed at the dawn of life, moving electrons in early metabolic cycles.
Image: Vikas Nanda

The primordial peptide may have appeared 4 billion years ago. How did life arise on Earth? Rutgers researchers have found among the first and perhaps only hard evidence that simple protein catalysts – essential for cells, the building blocks of life, to function – may have existed when life began. Their study of a primordial peptide, or short protein, is published in the Journal of the American Chemical Society.

In the late 1980s and early 1990s, the chemist Günter W...

Illustration of a neutrophil cell membrane-coated nanoparticle.
Credit: Qiangzhe Zhang/Nature Nanotechnology

Engineers at the University of California San Diego have developed neutrophil “nanosponges” that can safely absorb and neutralize a variety of proteins that play a role in the progression of rheumatoid arthritis. Injections of these nanosponges effectively treated severe rheumatoid arthritis in two mouse models. Administering the nanosponges early on also prevented the disease from developing.

“Nanosponges are a new paradigm of treatment to block pathological molecules from triggering disease in the body,” said senior author Liangfang Zhang, a nanoengineering professor at the UC San Diego Jacobs School of Engineering...

During breast cancer, some cancer cells will leave the tumor to invade into nearby tissues. In this new paper, Salk scientists find that the gene Sox10 is important in activating this local invasion. Left panel: Significant numbers of invasive cancer cells with Sox10 (red) in them can be found outside of the tumor (green cells, outlined). Right panel shows the invasive cells’ proximity to blood vessels (white).
Credit: Salk Institute

A team at the Salk Institute has identified a master switch that appears to control the dynamic behavior of tumor cells that makes some aggressive cancers so difficult to treat. The gene Sox10 directly controls the growth and invasion of a significant fraction of hard-to-treat triple-negative breast cancers.

Recently, the Salk lab led by Professor Geoffrey Wa...