Category Biology/Biotechnology

Voxel-based morphometry (VBM) F-test result comparing three subjective age (SA) groups (younger, same and older) in Korean Social Life, Health and Aging Project (KSHAP) data (n = 68). Significant group differences in regional gray matter (GM) density are visualized (p < 0.01, uncorrected, k > 500). Post hoc pairwise t-tests of the three groups indicated whether family-wise error (FWE)-corrected (voxel-level or cluster-level p < 0.05) voxels were included in the initially identified F-test clusters.

The first study to link subjective age to biological age shows that elderly people who feel younger have less signs of brain aging. While everyone gets older, not everyone feels their age. A recent study finds that such feelings, called subjective age, may reflect brain aging...

Design of a TAM-targeting supramolecular therapeutic.

Supramolecule provides a double whammy to knock out cancer’s ‘eat-me-not’ signaling, keep macrophages on the attack. Researchers have found that cancer cells evade destruction by macrophages in 2 ways – by converting cells to become docile, M2 macrophages, and by sending out an ‘eat me not’ signal that tricks M1 macrophages into letting them be. Investigators have developed a therapeutic that delivers a double whammy to knock out both mechanisms.

Macrophages play a paradoxical role, with M1 macrophages rousing the immune system to action and M2 macrophages quelling inflammation...

Leakage of the vascular tracer (red) from dermal blood vessels (green) in systemic inflammation.
Credit: Laura Hakanpaa / Saharinen Lab.

Increased capillary permeability and subsequent leakage from the capillaries is associated with numerous difficult-to-cure diseases, including acute respiratory distress syndrome (ARDS), severe Dengue fever and malaria, and sepsis. Currently, there is no effective therapy to inhibit capillary leakage and to maintain vessel stability in these diseases. The latest research published in the Proceedings of the National Academy of Sciences indicates that a monoclonal antibody targeted against β1-integrin inhibits vascular leakage in a mouse model of sepsis.

Integrins are heterodimeric cell surface receptors that mediate interactions between cells and the surro...