Category Biology/Biotechnology

The Na/K-ATPase Oxidant Amplification Loop Regulates Aging

Effects of pNaKtide on adipocyte phenotype, senescence, and apoptosis in C57Bl6 aging mice. (A) H&E staining in visceral adipose tissue. Images taken with 40X objective lens; scale bar represents 100 µm. Arrows mark “crown like structures” indicative of inflammation. (B) Quantitative analysis of adipocytes area in visceral adipose tissue. (C) Representative images of TUNEL assay with quantification in C57B16 aging mice. Images taken with 40X objective lens; scale bar represents 25 µm. (D–F) qRT-PCR analysis of ApoJ, p21 and PPARγ in C57Bl6 aging mice with GAPDH as a loading control. Y, young; Y + P, young + pNaKtide; OB, old baseline; O, old; O + P, old + pNaKtide; O + WD, old + western diet; O + WD + P, old + western diet + pNaKtide. N = 8/group, *p < 0.05, **p < 0.01 vs Y, #p < 0.05, ##p < 0.01 vs O, &p < 0.05, &&p < 0.01 vs O + WD.

Effects of pNaKtide on adipocyte phenotype, senescence, and apoptosis in C57Bl6 aging mice. (A) H&E staining in visceral adipose tissue. Images taken with 40X objective lens; scale bar represents 100 µm. Arrows mark “crown like structures” indicative of inflammation. (B) Quantitative analysis of adipocytes area in visceral adipose tissue. (C) Representative images of TUNEL assay with quantification in C57B16 aging mice. Images taken with 40X objective lens; scale bar represents 25 µm. (D–F) qRT-PCR analysis of ApoJ, p21 and PPARγ in C57Bl6 aging mice with GAPDH as a loading control. Y, young; Y + P, young + pNaKtide; OB, old baseline; O, old; O + P, old + pNaKtide; O + WD, old + western diet; O + WD + P, old + western diet + pNaKtide. N = 8/group, *p < 0.05, **p < 0...

Read More

Computational Model analysis reveals Serotonin Speeds Learning

A new computational-model designed by researchers at UCL based on data from the Champalimaud Centre for the Unknown reveals that serotonin, one of the most widespread chemicals in the brain, can speed up learning.

A new computational-model designed by researchers at UCL based on data from the Champalimaud Centre for the Unknown reveals that serotonin, one of the most widespread chemicals in the brain, can speed up learning.

Study provides insight into the role of serotonin in neural plasticity. A new computational-model designed by researchers at UCL based on data from the Champalimaud Centre for the Unknown reveals that serotonin, one of the most widespread chemicals in the brain, can speed up learning.

Serotonin is thought to mediate communications between neural cells and play an essential role in functional, and dysfunctional, cognition...

Read More

Low-cost Plastic Sensors could Monitor a Range of Health Conditions

A low-cost sensor made from semiconducting plastic could be used to diagnose or monitor a wide range of health conditions, such as surgical complications or neurodegenerative diseases. Credit: KAUST

A low-cost sensor made from semiconducting plastic could be used to diagnose or monitor a wide range of health conditions, such as surgical complications or neurodegenerative diseases. Credit: KAUST

An international team of researchers have developed a low-cost sensor made from semiconducting plastic that can be used to diagnose or monitor a wide range of health conditions, such as surgical complications or neurodegenerative diseases. The sensor can measure the amount of critical metabolites, such as lactate or glucose, that are present in sweat, tears, saliva or blood, and, when incorporated into a diagnostic device, could allow health conditions to be monitored quickly, cheaply and accurately...

Read More

Scientists developing Guidebook for Finding Life beyond Earth

Summary of gaseous, surface, and temporal biosignatures.

Summary of gaseous, surface, and temporal biosignatures.

Some of the leading experts in the field, including a UC Riverside team of researchers, have written a major series of review papers on the past, present, and future of the search for life on other planets. Published in Astrobiology, the papers represent two years of work by the Nexus for Exoplanet Systems Science (NExSS), a NASA-coordinated research network dedicated to the study of planetary habitability, and by NASA’s Astrobiology Institute.

Scientists have identified more than 3,500 exoplanets and many more will be discovered in the coming decades. Some of these are rocky, Earth-sized planets that are in the habitable zones of their stars, i.e. it’s neither too hot nor too cold for liquid water – and possibly life – to exist...

Read More