Category Biology/Biotechnology

Eating a high-fat diet containing a large amount of oleic acid—a type of fatty acid commonly found in olive oil—could drive obesity more than other types of dietary fats, according to a study published in the journal Cell Reports.

The study found that oleic acid, a monounsaturated fat associated with obesity, causes the body to make more fat cells. By boosting a signaling protein called AKT2 and reducing the activity of a regulating protein called LXR, high levels of oleic acid resulted in faster growth of the precursor cells that form new fat cells.

“We know that the types of fat that people eat have changed during the obesity epidemic...

As artificial intelligence and smart devices continue to evolve, machine vision is taking an increasingly pivotal role as a key enabler of modern technologies...

A newly discovered mechanism that leads to liver dysfunction may be a key factor in type 2 diabetes and other metabolic disorders in individuals with obesity, according to a new study led by Harvard T.H. Chan School of Public Health.

The dysfunction identified—dysregulated hepatic coenzyme Q metabolism—leads to excessive reactive oxygen species (ROS) produced by mitochondria at a single specific site in an enzyme called complex I. The researchers say the discovery offers a potential path for new, precise treatments for metabolic diseases.

“Our findings provide the first step toward solving a complex problem in the field of metabolic disease research that has stood for three decades,” said corresponding author Gökhan S...

A team of scientists at the Research Institute of the McGill University Health Center (The Institute) has made a landmark discovery that sheds light on how the immune system protects the gut during infection. By studying intestinal worms—also known as helminths—the team, led by Professor Irah King, uncovered a previously unknown immune mechanism that preserves intestinal function in the presence of persistent infection.

Their finding, published in the journal Cell, could pave the way for new treatments for helminth infections, which affect over two billion people worldwide at some point in their lives, as well as for other intestinal diseases.

The results could also help revisit older therapeutic strategies that were previously dismissed due to an incomplete understanding of...