Category Biology/Biotechnology

This is an illustration of the active state kappa opioid receptor bound to a morphine derivative (purple). Credit: Tao Che and Daniel Wacker, Roth Lab, UNC School of Medicine

Researchers show how to activate only one kind of brain receptor vital for pain relief, a key step in the creation of better pain medications. For the first time, scientists at the University of North Carolina School of Medicine and collaborators solved the crystal structure of the activated kappa opioid receptor bound to a morphine derivative. They then created a new drug-like compound that activates only that receptor, a key step in the development of new pain medications. The research shows a route toward creating opioids that relieve pain without causing the severe side effects at the heart of the opioid epidemic.

A schematic of development of Gamillus. Gene of the fluorescent protein was cloned from tentacles of flower hat jellyfish, and was engineered to improve the monomeric property and the brightness. Credit: Kamo Aquarium and Osaka University (The flower hat jellyfish was provided by Mr. Kamoizumi in Kamo Aquarium, Yamagata, Japan.)

Osaka University researchers develop new green fluorescent protein that can withstand low pH environment for imaging of acidic organelles. Visualizing cellular components and processes at the molecular level is important for understanding the basis of any biological activity. Fluorescent proteins (FPs) are one of the most useful tools for investigating intracellular molecular dynamics.

However, FPs have usage limitations for imaging in low pH environments, such as ...

Doctoral students Alan Chiu, left, and Duo An hold a sample of TRAFFIC (Thread-Reinforced Alginate Fiber for Islets enCapsulation). In the background, left to right, are Minglin Ma, Dan Luo, Meredith Silberstein and Dr. James Flanders. Credit: Lindsay France/University Photography

For the more than 1 million Americans who live with type 1 diabetes, daily insulin injections are literally a matter of life and death. And while there is no cure, a Cornell University-led research team has developed a device that could revolutionize management of the disease. In Type 1 diabetes, insulin-producing pancreatic cell clusters (islets) are destroyed by the body’s immune system...

The Human Connectome

A new and relatively simple technique for mapping the wiring of the brain has shown a correlation between how well connected an individual’s brain regions are and their intelligence, say researchers at the University of Cambridge. In recent years, there has been a concerted effort among scientists to map the connections in the brain – connectome’ – and to understand how this relates to human behaviours, such as intelligence and mental health disorders.

Now, in research published in the journal Neuron, an international team led by scientists at the University of Cambridge and the National Institutes of Health (NIH), USA, has shown that it is possible to build up a map of the connectome by analysing conventional brain scans taken using an MRI scanner...