Category Biology/Biotechnology

Immune Complex Shaves Stem Cells to Protect Against Cancer

extended data figure 18
Proposed model – The stromal inflammasome maintains tissue equilibrium by restraining Ras activity to impede premalignant-to-malignant transition.

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, according to a preclinical study by Weill Cornell Medicine investigators.

The study, published in Nature Immunology, may lead to therapies that target the earliest stages of cancer. The findings bolster the idea that the inflammasome has a dual role: It promotes inflammation associated with poor outcomes in late cancer stages, but early on, it can help prevent cells from becoming cancerous in the first place.

“What was striking was that the in...

Read More

Fiber may help Protect your Gut from Overgrowth of Harmful Bugs—new study

Our body isn’t just human—it’s home to trillions of microorganisms found in or on us. In fact, there are more microbes in our gut than there are stars in the Milky Way. These microbes are essential for human health, but scientists are still figuring out exactly what they do and how they help.

In a new study, published in Nature Microbiology, my colleagues and I explored how certain gut bacteria—a group known as Enterobacteriaceae—can protect us from harmful ones. These bacteria include species such as Escherichia coli (E coli). This is normally harmless in small amounts but can cause infections and other health problems if it grows too much.

We found that our gut environment—shaped by things like diet—plays a big role in keeping potentially harmful bacteria in check.

...Read More

Diet, Microbes and Fat: A new pathway controlling levels of body fat and cholesterol

Diet, microbes and fat: A new pathway controlling levels of body fat and cholesterol
Lipid accumulation in a murine model of fatty liver disease, visualized by color-enhanced lipid droplets (pink) in liver tissue (green). Superimposed chemical structure of a newly discovered bile acid conjugate. Credit: Dr. Mohammad Arifuzzaman, Dr. Christopher Parkhurst, Dr. Frank Schroeder, and Dr. David Artis.

Beneficial gut microbes and the body work together to fine-tune fat metabolism and cholesterol levels, according to a new preclinical study by investigators from Weill Cornell Medicine and the Boyce Thompson Institute at Cornell University’s Ithaca campus.

The research is published in the journal Nature.

The human body has co-evolved with the beneficial microbes that live in the gut (termed the microbiota), resulting in mutually favorable relationships that aid in the d...

Read More

Words Activate Hidden Brain Processes Shaping Emotions, Decisions and Behavior

Words activate hidden brain processes shaping emotions, decisions, and behavior
Emotional words evoke region- and valence-specific patterns of concurrent neuromodulator release in the human thalamus and cortex. Batten et al/Cell Reports. Credit: Batten et al/Cell Reports

In an unprecedented new study, researchers have shown neurotransmitters in the human brain are released during the processing of the emotional content of language, providing new insights into how people interpret the significance of words.

The work, conducted by an international team led by Virginia Tech scientists, offers deeper understanding into how language influences human choices and mental health.

Spearheaded by computational neuroscientist Read Montague, a professor of the Fralin Biomedical Research Institute at VTC and director of the institute’s Center for Human Neuroscience Resear...

Read More