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    Category Biology/Biotechnology

    Novel Treatment causes Cancer to Self-destruct without affecting Healthy Cells

    October 10, 2017, Categories  Health/Medical, Biology/Biotechnology

    Credit: Albert Einstein College of Medicine This image depicts the structure of the BAX protein (purple). The activator compound BTSA1 (orange) has bound to the active site of BAX (green), changing the shape of the BAX molecule at several points (shown in yellow, magenta and cyan). BAX, once in its final activated form, can home in on mitochondria and puncture their outer membranes, triggering apoptosis (cell death).

    Credit: Albert Einstein College of Medicine
    This image depicts the structure of the BAX protein (purple). The activator compound BTSA1 (orange) has bound to the active site of BAX (green), changing the shape of the BAX molecule at several points (shown in yellow, magenta and cyan). BAX, once in its final activated form, can home in on mitochondria and puncture their outer membranes, triggering apoptosis (cell death).

    Scientists at Albert Einstein College of Medicine have discovered the first compound that directly makes cancer cells commit suicide while sparing healthy cells. The new treatment approach, described in today’s issue of Cancer Cell, was directed against acute myeloid leukemia (AML) cells but may also have potential for attacking other types of cancers.

    “We’re hopeful that the t...

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    Genetic Body/Brain Connection Identified in Genomic Region linked to Autism

    October 8, 2017, Categories  Health/Medical, Biology/Biotechnology

    Jasmine M. McCammon, Alicia Blaker-Lee, Xiao Chen, Hazel Sive. The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. Human Molecular Genetics, 2017; DOI: 10.1093/hmg/ddx255

    Jasmine M. McCammon, Alicia Blaker-Lee, Xiao Chen, Hazel Sive. The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. Human Molecular Genetics, 2017; DOI: 10.1093/hmg/ddx255

    For the first time, Whitehead Institute scientists have documented a direct link between deletions in two genes – fam57ba and doc2a – in zebrafish and certain brain and body traits, such as seizures, hyperactivity, enlarged head size, and obesity. “Finding the molecular connections between a brain and a body phenotype is indeed really paradigm shifting,” says Whitehead Institute Member Hazel Sive, who is also a professor of biology at MIT...

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    Monitoring Microbes to Keep Marsonauts Healthy

    October 8, 2017, Categories  Astronomy/Space, Biology/Biotechnology

    Timeline of the Mars500 experiment from the beginning (3rd of June, 2010) until the end (5th of November, 2011). The schematic drawing also indicates important steps and events during the confinement (above timeline) including the two off-nominal situations (critical situation simulations) and sampling dates from 18 sampling events. Red area/font denotes the stay of three marsonauts in the simulated Martian surface complex, whereas light blue area represents the timeframe where the facility was untenanted. One reference sampling was performed 6 months after confinement. Crosses represent samples that were used for PhyloChip analyses or NGS, respectively. Samples from each sampling were subjected to cultivation experiments. Red: medical module EU-100; green: habitable module EU-150; blue: utility module EU-250. Yellow stars indicate changing of NANO-filters and cleaning events of the primary filters on day 162 (11th of November, 2010) and 243 (2nd of February, 2011) of isolation

    Timeline of the Mars500 experiment from the beginning (3rd of June, 2010) until the end (5th of November, 2011). The schematic drawing also indicates important steps and events during the confinement (above timeline) including the two off-nominal situations (critical situation simulations) and sampling dates from 18 sampling events. Red area/font denotes the stay of three marsonauts in the simulated Martian surface complex, whereas light blue area represents the timeframe where the facility was untenanted. One reference sampling was performed 6 months after confinement. Crosses represent samples that were used for PhyloChip analyses or NGS, respectively. Samples from each sampling were subjected to cultivation experiments...

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    Why do we Fall Asleep when Bored?

    October 1, 2017, Categories  Health/Medical, Biology/Biotechnology

    Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice. Nature Communications, 2017; 8 (1) DOI: 10.1038/s41467-017-00781-4

    Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice. Nature Communications, 2017; 8 (1) DOI: 10.1038/s41467-017-00781-4

    As humans, we often defy sleepiness and stay awake when attention is necessary, but also experience an inescapable desire to sleep in boring situations. The brain mechanisms governing the regulation of sleep by cognitive and emotional factors are not well understood. A new paper published in the journal Nature Communications finds that a part of the brain that is associated with motivation and pleasure – the nucleus accumbens – also can produce sleep. The new findings may explain why we have the tendency to fall asleep in the absence of motivating stimuli, i.e., when bored.

    Researchers at the University of Tsukuba’s International Institute ...

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