Category Biology/Biotechnology

Inflamed mouse colon mucosa, with an expanded population of intestinal stromal cells identified by expression of podoplanin (green). Epithelium is identified by expression of EpCAM (magenta); cyan, nuclei. Credit: Dr. Samuel Bullers

Kennedy Institute of Rheumatology and Translational Gastroenterology Unit, University of Oxford have identified a potential therapeutic target for IBD. The findings are of particular importance to the 40% of patients who don’t respond to anti-TNF therapy, the current treatment option available. The new study published in Nature Medicine shows that IBD patients have higher concentrations of Oncostatin M (OSM), a protein linked to inflammation, in their intestine and suggest that blocking OSM could prove to be a successful treatment for IBD.

The research also sho...

Charles Gersbach, the Rooney Family Associate Professor of Biomedical Engineering at Duke University. Credit: Duke University

Researchers have developed a method to swiftly the non-coding DNA of the human genome for links to diseases that are driven by changes in gene regulation. The technique could revolutionize modern medicine’s understanding of the genetically inherited risks of developing heart disease, diabetes, cancer, neurological disorders and others, and lead to new treatments.

“Identifying single mutations that cause rare, devastating diseases like muscular dystrophy has become relatively straightforward,” said Charles Gersbach, the Rooney Family Associate Professor of Biomedical Engineering at Duke University...

Under a microscope, root hairs grow into pyrogenic carbon particle, which enhance electron networks. Plants grow more efficiently than previously thought. Credit: Kelly Hanley/Lehmann Lab

All plants need electrons to aid biological and chemical tasks. Cornell scientists have discovered a new high-definition system that allows electrons to travel through soil farther and more efficiently than previously thought. “Microorganisms need electrons for everything they do. If they consume nutrients or spew out methane or expel carbon dioxide for any living, biological process they need electrons,” said Tianran Sun, postdoctoral researcher in soil and crop sciences.

Like large volumes of electricity that flow from Niagara Falls throughout upstate New York, electrons convey through soil via carbon...

Just five more minutes … can a coffee before a nap really help you pay back your sleep debt? Credit: www.shutterstock.com

Taking a nap is a common way of overcoming your sleepiness and repaying your sleep debt. Drinking coffee can also help us get through the day. In a 1997 study, 12 sleep-deprived people drank the equivalent of one large cup of brewed coffee and 5 minutes later had the chance to nap for 15 minutes. They then did some driving tests in a simulator to check their alertness. Although drinking a coffee (without a nap) helped their driving performance, combining caffeine with a nap (a coffee nap) improved it even further...