Aberrant spindles and impaired spindle poles in human cancer cells treated with the phenanthridine PJ34. (A) Small aberrant spindles were identified by confocal microscopy in randomly scanned human breast cancer MDA-MB-231 cells incubated with PJ34 (20 μM, 27 h). Spindles were immunolabeled for HSET/kifC1 (green) bound to microtubules. Similarly immunolabeled spindles are not impaired in PJ34 treated normal human breast epithelial cells MCF10A. Bars indicate the spindle length measured by the scale bar (n = 20; 3 different experiments), 95% of the spindles in MDA-MB-231 cells were shorter, 60 ± 5% in size. (B) Upper panel: Impaired spindle poles were identified in randomly scanned fixed MDA-MB-231 cells treated with PJ34 (20 μM, 27 h)...
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Category Biology/Biotechnology
Scientists discover Mechanism that causes Cancer Cells to Self-Destruct
March 27, 2017,
Health/Medical, Biology/Biotechnology
3D Bioprinted human Cartilage cells can be Implanted
March 25, 2017,
Health/Medical, Biology/Biotechnology
The illustration shows the formation of blood vessels, i.e., vascularisation, in the bioprinted material implanted in an animal model. Credit: Philip Krantz
Swedish researchers at Chalmers University of Technology and Sahlgrenska Academy have successfully induced human cartilage cells to live and grow in an animal model, using 3D bioprinting. The results will move development closer to a potential future in which it will be possible to help patients by giving them new body parts through 3D bioprinting. “This is the first time anyone has printed human-derived cartilage cells, implanted them in an animal model and induced them to grow,” says Paul Gatenholm, professor of biopolymer technology at Chalmers University of Technology.
Among else, Professor Gatenholm leads the research team working...
Read MoreComputer Program developed to Diagnose and Locate Cancer from a Blood Sample
March 24, 2017,
Health/Medical, Biology/Biotechnology
Flowchart of CancerLocator. Step 1: A set of solid tumor samples and healthy plasma samples collected from public databases and the literature are used to select the informative features (CpG clusters) that can differentiate tumor types or healthy plasma samples. Then the beta distributions of the methylation levels of these selected features for each tumor type or healthy plasma samples are learnt. Step 2: Given a plasma sample, the methylation profile of its cfDNAs is measured by whole-genome bisulfite sequencing, which is then used as input for cancer location prediction by CancerLocator
US Researchers have developed a computer program that can simultaneously detect cancer and identify where in the body the cancer is located, from a patient’s blood sample...
Read MoreCritical Step in DNA Repair, Cellular Aging Pinpointed
March 24, 2017,
Health/Medical, Biology/Biotechnology
A solid bond: New research led by Harvard Medical School reveals that interaction between the protein DBC1 and the signaling molecule NAD+ may help ward off DNA damage. Photo credit: David Bolinsky, e.mersion studios, 2017
DNA repair is essential for cell vitality, survival and cancer prevention, yet cells’ ability to patch up damaged DNA declines with age for reasons not fully understood. Now, research led by scientists at Harvard Medical School reveals a critical step in a molecular chain of events that allows cells to mend their broken DNA. The findings offer a critical insight into how and why the body’s ability to fix DNA dwindles over time and point to a previously unknown role for the signaling molecule NAD as a key regulator of protein-to-protein interactions in DNA repair...
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