Category Biology/Biotechnology

Cool image: Adding Color to the Gray world of Electron Microscopy

1. Color electron micrograph of an endosome, a cell organelle. Credit: Ranjan Ramachandra, UCSD 2. Check out more of our winter holiday-themed Cool Image collections

While it may look like a pine wreath dotted with crimson berries, it is in fact one of the world’s first color electron micrographs – and the method used to create it may dramatically advance cell imaging. As his Christmas gift to himself each year, the late biochemist Roger Tsien treated himself to 2 weeks of uninterrupted research in his lab. This image is a product of those annual sojourns.

Electron microscopy (EM) is a time-honored technique for visualizing cell structures that uses beams of accelerated electrons to magnify objects up to 10 million times their actual size...

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Rudolph’s Antlers inspire next Generation of Unbreakable Materials

Rudolph's antlers inspire next generation of unbreakable materials

Dark brown fallow deer (buck) with big antlers is shown. Credit: Wikipedia commons

Scientists from Queen Mary University of London (QMUL) have discovered the secret behind the toughness of deer antlers and how they can resist breaking during fights. The team looked at the antler structure at the nano-level and were able to identify the mechanisms at work, using state-of-the-art computer modelling and xray techniques.

Paolino De Falco from QMUL’s School of Engineering and Materials Science said: “The fibrils that make up the antler are staggered rather than in line with each other. This allows them to absorb the energy from the impact of a clash during a fight...

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Brain technique improves cognitive control

Stimulation of Dorsolateral Prefrontal Cortex Enhances Adaptive Cognitive Control: A High-Definition Transcranial Direct Current Stimulation Study Oyetunde Gbadeyan, Katie McMahon, Marco Steinhauser and Marcus Meinzer Journal of Neuroscience 14 December 2016, 36 (50) 12530-12536; DOI: https://doi.org/10.1523/JNEUROSCI.2450-16.2016

Stimulation of Dorsolateral Prefrontal Cortex Enhances Adaptive Cognitive Control: A High-Definition Transcranial Direct Current Stimulation Study Oyetunde Gbadeyan, Katie McMahon, Marco Steinhauser and Marcus Meinzer Journal of Neuroscience 14 December 2016, 36 (50) 12530-12536; DOI: https://doi.org/10.1523/JNEUROSCI.2450-16.2016

A cutting edge, non-invasive brain stimulation technique could improve cognitive control for people with conditions such as schizophrenia and autism, ADHD. Researchers at The University of Queensland’s Centre for Clinical Research have found the technique – which applies high-definition transcranial direct current stimulation to a particular area of the brain – improves cognitive and conflict control.

PhD candidate Oyetunde Gbadeyan said the study provides th...

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Turning therapeutic Antibodies inside-out to fight Cancer

Turning therapeutic antibodies inside-out to fight cancer

A schematic showing how a human monoclonal antibody containing a loop structure (CDR-H3) inspired by antibodies found naturally in camels can bind to matrix metalloproteinase 14, which has been shown to play a significant role in several types of cancer.

Researchers at the University of California, Riverside have camels and llamas to thank for their development of a new cancer treatment that is highly selective in blocking the action of faulty matrix metalloproteinases (MMPs). MMPs are a group of 26 closely related proteinases (enzymes that break down other proteins) that are essential in tissue regeneration and other normal cellular processes. However, when a tumor grows, certain MMPs are over-produced, allowing cancer cells to spread to other parts of the body.

Assistant professor Xin Ge...

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