Category Biology/Biotechnology

Reparative Effects of Interleukin-1 Receptor Antagonist in Young And Aged/Co-Morbid Rodents After Cerebral Ischemia. Brain, Behavior, and Immunity, 2016; DOI: 10.1016/j.bbi.2016.11.013

A potential new drug reduces the number of brain cells destroyed by stroke and then helps to repair the damage. A reduction in blood flow to the brain caused by stroke is a major cause of death and disability, and there are few effective treatments. A team of scientists at The University of Manchester has now found that a potential new stroke drug not only works in rodents by limiting the death of existing brain cells but also by promoting neurogenesis.

This finding provides further support for the development of this anti-inflammatory drug, interleukin-1 receptor antagonist (IL-1Ra in short), as a new treat...

This schematic representation illustrates the process of turning bagasse into carbon quantum dots. Credit: Elsevier

Indian researchers have found a new use for sugarcane pulp, as a source of highly fluorescent carbon quantum dots, in a study published in Applied Surface Science. This alternate use of sugarcane waste, or bagasse, could not only reduce the amount of agricultural waste contaminating the environment but also offers a new revenue stream for farmers.
“In our study, we developed a simple, low-cost and efficient method for green synthesis of fluorescent carbon quantum dots from sugarcane bagasse,” says Dr. Ravi Shankaran Dhesingh, National Centre for Nanoscience and Nanotechnology at the University of Madras, Chennai, India.

These dots are tiny carbon nanoparticles, which are abou...

Highlights SIP is a new protein phosphatase 2A-containing protein complex SIP is essential for the asymmetric localization of SIN components to the SPB SIP is required for the SPB localization of the SIN inhibitor Byr4p SIP promotes dephosphorylation of the SIN scaffold protein Cdc11p

A naturally occurring predatory bacterium is able to work with the immune system to clear multi-drug resistant Shigella infections in zebrafish. It is the first time the predatory bacterium Bdellovibrio bacteriovorus has been successfully used as an injected anti-bacterial therapy and represents an important step in the fight against drug-resistant infections, or ‘superbugs’.

Shigella infection is responsible for over 160 million illnesses and over 1 million deaths every year – and is a common cause of ‘trave...

Synovial Fibroblasts (SFs)  are cells that make up part of the connective tissue, or synovium, around human joints. In RA patients, SF cells cause damage by invading and attacking the cartilage and bone around the joint

A study reveals the key role of different types of fibroblast cells in the development of rheumatoid arthritis (RA), opening up a new avenue for research into treatment of the disease. Synovial Fibroblasts (SFs) are cells that make up part of the connective tissue, or synovium, around human joints. In RA patients, SF cells cause damage by invading and attacking the cartilage and bone around the joint.

A team from University of Birmingham’s Institute of Inflammation and Ageing identified 2 distinct types of SF within the synovial membrane...