Category Biology/Biotechnology

Left, the P domain on human norovirus attaches to human cells via binding to HBGA. Human IgA antibody 5I2 interferes with this attachment by physically blocking the HBGA recognition site on the P domain. Courtesy of S. Shanker, B.V.V. Prasad and M. Estes

A mechanism by which human antibodies target and block noroviruses has been found. It opens the possibility of developing therapeutic agents against this virus that causes the death of about 200,000 children every year. “Some people infected with norovirus do not get sick,” said Dr. B V Venkataram Prasad, professor of virology and the Alvin Romansky Chair in biochemistry at Baylor. “We wanted to understand how
these protective human antibodies work.”

The researchers screened and isolated protective antibodies from human blood and discovere...

Functional magnetic resonance imaging (fMRI) and other brain imaging technologies allow for the study of differences in brain activity in people diagnosed with schizophrenia. The image shows two levels of the brain, with areas that were more active in healthy controls than in schizophrenia patients shown in orange, during an fMRI study of working memory. Credit: Kim J, Matthews NL, Park S./PLoS One.

A key mechanism that explains how compounds researchers are developing can suppress schizophrenia-like symptoms in mice without side effects has been found. About 3 million Americans have schizophrenia, which is associated with excessive amounts of the neurotransmitter dopamine in a part of the forebrain called the striatum...

The Foldit puzzle-solving game, where groups compete online to fold the best protein. In a recent study, gamers beat scientists, college students and computer algorithms to see who could identify a particular protein’s shape. Credit: Scott Horowitz

Gamers playing the popular online puzzle game Foldit beat scientists, college students and computer algorithms in a contest to see who could identify a particular protein’s shape. The study findings have implications for video game enthusiasts and classroom instruction, and showcase the positive impact citizen science can have on research...

Methylmercury bioaccumulation

Cognitive function improves with aerobic exercise, but not for people exposed to high levels of mercury before birth, according to research funded by the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health. Adults with high prenatal exposure to methylmercury, which mainly comes from maternal consumption of fish with high mercury levels, did not experience the faster cognitive processing and better short term memory benefits of exercise that were seen in those with low prenatal methylmercury exposures.

This is one of the first studies to examine how methylmercury exposure in the womb may affect cognitive function in adults...