Category Biology/Biotechnology

Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria allows us to make the fuel we need from sugars, a process vital to all life on Earth.

Scientists at the Medical Research Council (MRC) Mitochondrial Biology Unit, University of Cambridge, have worked out the structure of this machine and shown how it operates like the lock on a canal to transport pyruvate—a molecule generated in the body from the breakdown of sugars—into our mitochondria.

Known as the mitochondrial pyruvate carrier, this molecular machine was first proposed to exist in 1971, but it has taken until now for scientists to visualize its structure at the atomic scale using cryo-electron microscopy, a technique used to ...

Bacteria naturally present in the human intestine (known as the gut microbiota) can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking androgen signaling, according to a preclinical study led by Weill Cornell Medicine investigators. The study was published on April 15 in Cell.

“I was very surprised by our findings. As far as I know, no one has previously discovered molecules like these bile acids that can interact with the androgen receptor in this way,” said co-senior author Dr...

Benzodiazepines like Valium and Xanax are often prescribed to treat anxiety, insomnia and seizures. While these drugs can be effective as a short-term treatment, researchers are trying to better understand the impact of benzodiazepines after extended use.

Some experts believe long-term use of the medication may influence inflammation levels in our bodies, as previous research has shown that benzodiazepines may increase the risk of developing or worsening inflammatory conditions, like lung inflammation and inflammatory bowel disease...

Humans and other animal species can experience many types of pain throughout the course of their lives, varying in intensity, unpleasantness, and origin. Several past neuroscience studies have explored the neural underpinnings of pain, yet the processes supporting the ability to distinguish different types of physical pain are not fully understood.

In most vertebrates, painful sensations are known to arise from the nervous system, which includes the brain, an intricate network of nerves and the spinal cord...