Category Biology/Biotechnology

This is an overview of designing and building a custom lab instrument using the Multifluidic Evolutionary Component (MEC) system created at UC Riverside. Credit: UC Riverside

Uni of CA, Riverside researchers have created a Lego-like system of blocks that enables users to custom make chemical and biological research instruments quickly, easily and affordably. The system of 3D-printed blocks can be used in university labs, schools, hospitals, and anywhere there is a need to create scientific tools.

Each block, called Multifluidic Evolutionary Components (MECs) because of their flexibility and adaptability, performs a basic task found in a lab instrument, like pumping fluids, making measurements or interfacing with a user...

Primary hippocampal neurons from mice express G2019S-LRRK2. The neurons were treated with alpha-synuclein fibrils, and 18 days later immunofluorescence was performed. The magenta shows phospho-alpha-synuclein inclusions in the cell bodies and throughout the axons, which are visualized as green. Credit: UAB

A team has shown the most common genetic cause of Parkinson’s disease – a mutant LRRK2 kinase enzyme – contributes to the formation of inclusions in neurons, resembling one of the hallmark pathologies seen in Parkinson’s disease. These inclusions are made up of aggregated alpha synuclein protein, which – the research also shows – can be prevented from forming by using 2 LRRK2 kinase inhibitor drugs now being developed for clinical use.

The interaction between mutant LRRK2 kinase and alph...

The synapses of pyramid cells in the cerebral cortex form functional groups. Some of the related synapses are shown in green in the reconstruction. Credit: MPI of Neurobiology / Scheuss

The contact points of cells in the cerebral cortex form functional groups. The cerebral cortex resembles a vast switchboard. Countless lines carrying information about the environment, for example from the sensory organs, converge in the cerebral cortex. In order to direct the flow of data into meaningful pathways, the individual pyramidal cells of the cerebral cortex act like miniature switchboard operators. Each cell receives information from several thousand lines. Scientists have shown for the first time that synapses between specific neuron types are clustered in groups on the target neuron...

Arun Kota’s superomniphobic device can sort droplets by surface tension. Credit: Sanli Movafaghi/Colorado State University

Imagine being able to instantly diagnose diabetes, Ebola or some other disease, simply by watching how a droplet of blood moves on a surface. That’s just one potential impact of new research led by Assistant Prof. Arun Kota, Colorado State University. Kota’s lab makes coatings that repel not just water, but virtually any liquid, including oils and acids – a property called superomniphobicity.

They did it by making their device’s surface tunable, meaning they can manipulate its surface chemistry to turn up or turn down how well it repels liquids...