Category Biology/Biotechnology

MIT researchers have developed a new way to image proteins and RNA inside neurons of intact brain tissue. Image: Yosuke Bando, Fei Chen, Dawen Cai, Ed Boyden, and Young Gyu

Microscopy technique allows pinpointing RNA molecules in the brain. Key to the new technique is expanding the tissue before imaging it so it can be seen at very high resolution using ordinary microscopes commonly found in research labs. “Now we can image RNA with great spatial precision, thanks to the expansion process, and we also can do it more easily in large intact tissues,” says A/Prof Ed Boyden.

Studying the distribution of RNA inside cells could help scientists learn more about how cells control their gene expression and could also allow them to investigate diseases thought to be caused by failure of RNA to m...

New research suggests that replacing saturated fats like butter, lard, and fat in red meat with unsaturated fats from plant-based foods — like olive oil, canola oil, and soybean oil — can confer substantial health benefits. Credit: © tanyasid / Fotolia

Consuming higher amounts of unsaturated fats was associated with lower mortality, according to a study from Harvard T.H. Chan School of Public Health. In a large study population followed for more than 3 decades, researchers found that higher consumption of saturated and trans fats was linked with higher mortality vs same number of calories from carbohydrates. Most importantly, replacing saturated fats with unsaturated fats conferred substantial health benefits...

Production of ImmuStick: Application of immune receptors onto the test strip. Credit: © Photo Fraunhofer IGB

At present, bacteria, fungi or viruses can generally only be detected with certainty by way of elaborate lab tests or animal experiments. The food and pharmaceutical industries would like to have faster tests to check their products. Fraunhofer researchers are therefore developing a stick that works like a pregnancy test and quickly delivers a result. In the future, it is also to be used for detecting allergens and disease pathogens in the blood.

“The ImmuStick can even detect pathogens outside the body – on medical devices or in hospital rooms for example. However, the technology would certainly also be of interest for testing human blood for germs or allergies,” says Dr...

Researchers working on inhalable ibuprofen to treat cystic fibrosis

In cystic fibrosis, high dose ibuprofen helps slow decline of lung function, a disease caused by having two ‘bad’ copies of a gene that codes for a protein important in fluid secretion. Improved lung function is important, given that most people diagnosed die by their early 50s, usually due to chronic lung infections caused by their inability to move particles, including bacteria, up and out of the lungs. The downside is that ibuprofen doses that high, when taken routinely, can result in gastrointestinal (GI) bleeding and – when combined with the antibiotics that these patients often have to take for their recurring lung infections – acute kidney injury...