Category Biology/Biotechnology

Diet, Microbes and Fat: A new pathway controlling levels of body fat and cholesterol

Diet, microbes and fat: A new pathway controlling levels of body fat and cholesterol
Lipid accumulation in a murine model of fatty liver disease, visualized by color-enhanced lipid droplets (pink) in liver tissue (green). Superimposed chemical structure of a newly discovered bile acid conjugate. Credit: Dr. Mohammad Arifuzzaman, Dr. Christopher Parkhurst, Dr. Frank Schroeder, and Dr. David Artis.

Beneficial gut microbes and the body work together to fine-tune fat metabolism and cholesterol levels, according to a new preclinical study by investigators from Weill Cornell Medicine and the Boyce Thompson Institute at Cornell University’s Ithaca campus.

The research is published in the journal Nature.

The human body has co-evolved with the beneficial microbes that live in the gut (termed the microbiota), resulting in mutually favorable relationships that aid in the d...

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Words Activate Hidden Brain Processes Shaping Emotions, Decisions and Behavior

Words activate hidden brain processes shaping emotions, decisions, and behavior
Emotional words evoke region- and valence-specific patterns of concurrent neuromodulator release in the human thalamus and cortex. Batten et al/Cell Reports. Credit: Batten et al/Cell Reports

In an unprecedented new study, researchers have shown neurotransmitters in the human brain are released during the processing of the emotional content of language, providing new insights into how people interpret the significance of words.

The work, conducted by an international team led by Virginia Tech scientists, offers deeper understanding into how language influences human choices and mental health.

Spearheaded by computational neuroscientist Read Montague, a professor of the Fralin Biomedical Research Institute at VTC and director of the institute’s Center for Human Neuroscience Resear...

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Mediterranean Diet Linked to Improved Memory via Gut Bacteria Changes

Mediterranean diet
The Mediterranean diet focuses on fruits, vegetables, whole grains, olive oil, fish and legumes. Photo by Shutterstock

A new Tulane University study suggests the Mediterranean diet’s brain-boosting benefits may work by changing the balance of bacteria in the gut.

In a study published in Gut Microbes Reports, researchers at Tulane University School of Medicine found that subjects following a Mediterranean diet developed distinctly different gut bacteria patterns compared to those eating a typical Western diet. These bacterial changes correlated with better memory and cognitive performance.

“We’ve known that what we eat affects brain function, but this study explores how that could be happening,” said lead author Rebecca Solch-Ottaiano, Ph.D...

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Gene Therapy Research offers hope for people with Chronic Kidney Disease

Gene therapy research offers hope for people with chronic kidney disease
A mechanistic model of AAV9 and AAV-KP1-mediated renal transduction. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-54475-9

Researchers are making strides in improving gene therapies for genetic diseases, particularly chronic kidney disease, using adeno-associated virus, or AAV, vectors. While AAV-based treatments have shown promise, delivering these therapies effectively to the kidneys has remained a challenge—until now.

There are many different types of AAV capsids—the protein shells of virus particles—that have been used to deliver genes to cells, each with unique effects...

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