Category Biology/Biotechnology

Highlights • Arid1a loss results in improved regeneration after diverse liver injuries • Arid1a overexpression impairs liver proliferation and regeneration • Arid1a loss also improves tissue repair after ear hole punch • Arid1a loss remodels chromatin, altering transcriptional access by C/EBPα and E2F4

The liver is unique among human solid organs in its robust regenerative capability. This research gives us ideas about new ways to treat liver damage or chronic liver disease,” said Dr. Hao Zhu, an Assistant Professor at CRI. Tails in lizards and arms in starfish show an astounding ability to regrow, but mammals have partially lost the capacity to extensively regenerate body parts, Dr. Zhu said. The liver is unique among human solid organs in its robust regenerative capability...

Omega-6 unsaturated fatty acid (linoleic acid, LA),

A new study from the University of Eastern Finland shows that high serum omega-6 polyunsaturated fatty acid concentrations are linked to a significantly reduced risk of type 2 diabetes. The findings were published in the American Journal of Clinical Nutrition.

It has been speculated that a high intake of omega-6 polyunsaturated fatty acids may increase the risk of several chronic diseases, as these fatty acids have been suggested to promote low-grade inflammation, among other things. However, studies conducted on humans have not established a link between even a high intake of omega-6 fatty acids and inflammation. Furthermore, omega-6 fatty acids have beneficial effects on, for example, glucose metabolism...

Heat inducible expression of pdgf-b mRNA in transgenic PD-1 L. sericata. a Schematic of heat-inducible pdgf-b gene construct in a piggyBac transformation vector with a ZsGreen marker gene. b Genomic DNA sequence adjacent to the 5′ pBac end in the PD-1 transgenic line. The TTAA insertion site is underlined. c RT-PCR amplification of pdgf-b on total RNA obtained from first instar PD-1 larvae that had been given a heat shock (+HS) or no heat shock (-HS)

Genetically engineered green bottle fly larvae (Lucilia sericata) can produce and secrete a human growth factor – a molecule that helps promote cell growth and wound healing...

Man unable to sleep (stock image). Acute sleep loss in humans is associated with increased appetite and insulin insensitivity, while chronically sleep-deprived individuals are more likely to develop obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Credit: © Focus Pocus LTD / Fotolia

A new study is the first to identify that a conserved gene – translin – works as a modulator of sleep in response to metabolic changes. The sleep habits of fruit flies are remarkably similar to humans. They get most of their sleep at night, certain drugs and stimulants like caffeine can negatively affect their sleep, and if they get a lousy night’s sleep it can even affect their memory performance.

When fruit flies are hungry, they sleep less because they will sacrifice sleep for their...