Category Biology/Biotechnology

Photocleavable Hydrogel-Coated Upconverting Nanoparticles: A Multifunctional Theranostic Platform for NIR Imaging and On-Demand Macromolecular Delivery. Lanthanide-doped upconverting nanoparticles (UCNPs) have emerged as excellent nanotransducers for converting longer wavelength near-infrared (NIR) light to shorter wavelengths spanning the UV to visible (Vis) regions of the spectrum via a multiphoton absorption process, known as upconversion. Here, we report the development of NIR to UV–Vis–NIR UCNPs consisting of LiYF4:Yb3+/Tm3+@SiO2 individually coated with a 10 ± 2 nm layer of chitosan (CH) hydrogel cross-linked with a photocleavable cross-linker (PhL).

Some drug regimens, eg those designed to eliminate tumors, are notorious for nasty side effects...

The zinnia plants began to exhibit guttation and epinasty, both signs of plant stress. Credit: NASA

When Scott Kelly tweeted a picture of moldy leaves on the current crop of zinnia flowers aboard ISS, it could have looked like the science was doomed. It was in fact an opportunity for scientists back on Earth to better understand how plants grow in microgravity, and for astronauts to practice doing what they’ll be tasked: autonomous gardening.

The Veggie plant growth facility was installed on the orbiting laboratory in early May of 2014, and the first crop – ‘Outredgrous’ red romaine lettuce – was activated for growth. The first growth cycle faced some issues...

Short bursts of Intensive Exercise provide a more “time-efficient” and realistic way of preventing, delaying and managing Type 2 diabetes and also losing weight. Obesity and Type 2 diabetes are linked, with >80% of people with the condition classed as overweight or obese – diet and physical activity interventions are the cornerstones for management of both conditions.

The effects of exercise on Type 2 diabetes and improving the body’s ability to use insulin to absorb blood sugar are well established, but its impact on weight regulation is more controversial...

Researchers from the Walter and Eliza Hall Institute in Melbourne, Australia, have shown they can stop leukemia in its tracks by targeting a protein that puts the handbrake on cancer cell growth. The researchers discovered that targeting a protein called Hhex could cure acute myeloid leukemia (AML) in preclinical disease models, and could be a key target for new therapies for human leukemia. Credit: Walter and Eliza Hall Institute

Melbourne researchers have showed that they can stop leukemia in its tracks by targeting a protein that puts the handbrake on cancer cell growth.They discovered targeting protein Hhex could cure acute myeloid leukemia (AML) in preclinical disease models, and could be a key target for new therapies for human leukemia...