Category Biology/Biotechnology

Highlights •A triple-target CRISPR method achieved almost perfect knockout efficiency •SSS achieved non-invasive fully automated high-performance sleep phenotyping •Genetics without crossing revealed Nr3a as a short-sleeper gene

You may have wondered why some people seem to need less sleep. A number of so called short-sleeper genes, which are associated with little need for sleep, have recently been identified. RIKEN Quantitative Biology Center (QBiC) researchers have advanced sleep genetics research by developing a new method for monitoring mouse sleep cycles. The Snappy Sleep Stager is a non-invasive, automated sleep cycle monitoring system based on mouse respiration, or breathing...

This is a gold nanoparticle, brought into contact to a DNA nanostructure, sticks to chemical patches. Scientists then dissolve the assembly, separating the DNA nanostructure into its component strands and leaving behind the DNA imprint on the gold nanoparticle. Credit: Thomas Edwardson

New technique could facilitate use of gold nanoparticles in electronic, medical applications. Gold nanoparticles have unusual optical, electronic and chemical properties, which scientists are seeking to put to use in a range of new technologies, from nanoelectronics to cancer treatments.

Some of the most interesting properties of nanoparticles emerge when they are brought close together – either in clusters of just a few particles or in crystals made up of millions of them...

Coffee flour. Credit: Image courtesy of Brandeis University

Biophysicist Perlman is developing the flour milled from parbaked beans both as a food ingredient and a nutritional supplement. “It’s a world of difference” from the traditional coffee bean, Perlman says. Research has shown that drinking coffee is good for you. A recent Harvard study found that people who drank three to five cups a day had a 15% lower chance of prematurely dying than non-drinkers.

Nobody knows for certain what causes coffee to be salutary, but one leading explanation involves a natural chemical compound called chlorogenic acid (CGA). An antioxidant, CGA is thought to be beneficial in modulating sugar metabolism, controlling BP and possibly treating heart disease and cancer.

Unfortunately, when coffee is roasted th...

Highlights • Genetic loss of PHD1 provides substantial protection against brain ischemic injury • PHD1 loss reprograms glucose metabolism without vascular changes • Increased oxPPP flux, at the expense of glycolysis, enhances redox balance in neurons • Intracerebroventricular delivery of anti-PHD1 oligos protects against stroke

Despite (minor) improvements in stroke treatment, stroke remains the 4th leading cause of death and the most common reason of severe disability. Research led by Prof. Peter Carmeliet and Dr. Annelies Quaegebeur (VIB/KU Leuven) indicates inhibition of PHD1 offers protection against stroke, via an unexpected mechanism, raising hope for future stroke treatment.

Brain cells rely on oxygen and glucose to generate energy, necessary to function normally...