Category Biology/Biotechnology

Binding of p53 to non‐canonical response elements in human subtelomeres confers enhancer‐like activities and correlates with increased telomere stability. Non‐canonical p53 binding sites were identified in the subtelomeres of both human and mouse. Subtelomeric p53 response elements confer transcription activation in vitro and p53‐dependent induction of TERRA, eRNA‐like transcripts, and more distal subtelomeric genes. p53 status correlates with enhanced telomere stability and survival in response to etoposide‐induced DNA damage. Stress‐induced p53 binding to the subtelomere correlates with increased histone acetylation and decreased γH2AX. CRISPR deletion of the p53 response element ameliorates these effects.

New research shows p53 is able to suppress accumulated DNA damage a...

A thin, flexible film developed by researchers from the University of Michigan can detect biomarkers of cancer in the blood. It may eventually lead to the development of phone-sized cancer detection devices. (Photo : Public Domain Pictures | Pixabay

A thin, stretchable film that coils light waves like a Slinky could one day lead to more precise, less expensive monitoring for cancer survivors. The Uni of Michigan chemical engineers who developed the film say it could help patients get better follow-up Rx with less disruption to their everyday lives.
The film provides a simpler, more cost-effective way to produce circularly polarized light, an essential ingredient in the process that could eventually provide an early warning of cancer recurrence.

Circular polarization is similar to the linea...

A new study found eating less fiber, more saturated fat, sugar is associated with lighter, less restorative, and more disrupted sleep. Results show that greater fiber intake predicted more time spent in deep, slow wave sleep. In contrast, a higher percentage of energy from saturated fat predicted less slow wave sleep. Greater sugar intake also was associated with more arousals from sleep.

“Our main finding was that diet quality influenced sleep quality,” said Marie-Pierre St-Onge, PhD, assistant professor in the department of medicine and Institute of Human Nutrition at Columbia University Medical Center in New York, N.Y. “It was most surprising that a single day of greater fat intake and lower fiber could influence sleep parameters.”

The study also found that participants fell asleep fas...

Linactolide

In mice, investigators found a high caloric diet turned off expression of a key hormone in the intestine, which led to deactivation of a tumor suppressor pathway. Genetic replacement of that hormone turned the tumor suppressor back on and prevented cancer development – even when mice continued to eat excess calories.

These findings position the use of the pill linaclotide (Linzess), which is structurally related to the lost hormone, as a therapeutic approach to preventing colorectal cancer in obese patients. The FDA approved linaclotide in 2012 to treat IBS with constipation as well as chronic idiopathic constipation (chronic constipation from unknown causes)...